ArticleAnnals of internal medicine2019
General and Abdominal Adiposity and Mortality in Mexico City: A Prospective Study of 150 000 Adults.
Article in Annals of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trial.Cardiovascular diabetology · 2023Trial
- Adiposity and infection-related mortality: Mendelian randomization study of 126 000 Mexican adults.International journal of epidemiology · 2026Article
- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- Which adiposity marker is most strongly associated with all‑cause and cause‑specific mortality? a prospective study of 158,699 Mexican adults.International journal of obesity (2005) · 2025Article
- Improving estimators of HIV mortality and retention in care by linking clinical cohort data with national registries in Mexico.BMC public health · 2025Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- A Mendelian randomization study of the effect of body mass index on 52 causes of death among 125 000 Mexican adults with admixed ancestry.International journal of epidemiology · 2025Article
- Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Global health 2050: the path to halving premature death by mid-century.Lancet (London, England) · 2024Review
- Obesity and cardiovascular risk: a primer for the clinician.Archivos de cardiologia de Mexico · 2024Review
- Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.International journal of epidemiology · 2024Article
- The association of ALT to HDL-C ratio with type 2 diabetes in 50-74 years old adults: a population-based study.Scientific reports · 2024Article
- Dose-response association of diabetic kidney disease with routine clinical parameters in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- General or Central Obesity and Mortality Among US Hispanic and Latino Adults.JAMA network open · 2024Article
- The inverted U-shaped relationship between weight loss percentage and cardiovascular health scores.Eating and weight disorders : EWD · 2023Article
- Educational and social inequalities and cause-specific mortality in Mexico City: a prospective study.The Lancet. Public health · 2023Article
- Waist-to-Height Ratio: A Sensitive Tool for Assessing the Need for Nutritional Risk Management in Elderly Populations from Brazil.Healthcare (Basel, Switzerland) · 2023Article
- Body Composition and Risk of Vascular-Metabolic Mortality Risk in 113 000 Mexican Men and Women Without Prior Chronic Disease.Journal of the American Heart Association · 2023Article
- Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults.Communications medicine · 2022Article
- Testing positive, losing a loved one, and financial hardship: Real-world impacts of COVID-19 on US college student distress.Journal of affective disorders · 2022Article
Corrections and comments
- Commented on by
Authors and funding
17 authors.
Funding
Abstract
Background: Some reports suggest that body mass index (BMI) is not strongly associated with mortality in Hispanic populations. Objective: To assess the causal relevance of adiposity to mortality in Mexican adults, avoiding reverse causality biases. Design: Prospective study. Setting: 2 Mexico City districts. Participants: 159 755 adults aged 35 years and older at recruitment, followed for up to 14 years. Participants with a hemoglobin A1c level of 7% or greater, diabetes, or other chronic diseases were excluded. Measurements: BMI, waist-to-hip ratio, waist circumference, and cause-specific mortality. Cox regression, adjusted for confounders, yielded mortality hazard ratios (HRs) after at least 5 years of follow-up and before age 75 years. Results: Among 115 400 participants aged 35 to <75 years at recruitment, mean BMI was 28.0 kg/m2 (SD, 4.1 kg/m2) in men and 29.6 kg/m2 (SD, 5.1 kg/m2) in women. The association of BMI at recruitment with all-cause mortality was J-shaped, with the minimum at 25 to <27.5 kg/m2. Above 25 kg/m2, each 5-kg/m2 increase in BMI was associated with a 30% increase in all-cause mortality (HR, 1.30 [95% CI, 1.24 to 1.36]). This association was stronger at ages 40 to <60 years (HR, 1.40 [CI, 1.30 to 1.49]) than at ages 60 to <75 years (HR, 1.24 [CI, 1.17 to 1.31]) but was not materially affected by sex, smoking, or other confounders. The associations of mortality with BMI and waist-to-hip ratio were similarly strong, and each was weakened only slightly by adjustment for the other. Waist circumference was strongly related to mortality and remained so even after adjustment for BMI and hip circumference. Limitation: Analyses were limited to mortality. Conclusion: General, and particularly abdominal, adiposity were strongly associated with mortality in this Mexican population. Primary Funding Source: Mexican Health Ministry, Mexican National Council of Science and Technology, Wellcome Trust, Medical Research Council, and Kidney Research UK.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.