Evidence map›Paper›PMID 31404788›Full record

ReviewCurrent opinion in genetics & development2019

Sticking to a plan: adhesion and signaling control spatial organization of cells within migrating collectives.

Frank Macabenta, Angelike Stathopoulos

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Collective Migrations ofGenetics · 2020
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Frank MacabentaCalifornia Institute of Technology, 1200 East California Blvd., Pasadena, CA 91125, United States. Electronic address: frankmac@caltech.edu.
Angelike StathopoulosCalifornia Institute of Technology, 1200 East California Blvd., Pasadena, CA 91125, United States. Electronic address: angelike@caltech.edu.
California Institute of Technology · US

Funding

Temporal control of cell patterning, signaling, and movement in early embryosR35GM118146 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STATHOPOULOS, ANGELIKE · 2016 to 2025
$5.8M
NIGMS NIH HHS R35 GM118146
6 · The paper itself

Abstract

Collective cell migration is required in a vast array of biological phenomena, including organogenesis and embryonic development. The mechanisms that underlie collective cell migration not only involve the morphogenetic changes associated with single cell migration, but also require the maintenance of cell-cell junctions during movement. Additionally, cell shape changes and polarity must be coordinated in a multicellular manner in order to preserve directional movement in the migrating cohort, and often relates to multiple functions of common signaling pathways. In this review, we summarize the current understanding of the mechanisms underlying higher order tissue organization during migration, with particular focus on the interplay between cell adhesion and signaling that we propose can be tuned to support different types of collective movements.

Indexed as

AnimalsCell MovementEmbryonic DevelopmentIntercellular JunctionsMorphogenesisOrganogenesisSignal Transduction

Identifiers

PMID31404788
PMCPMC6927539
OpenAlexW2967311405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.