Evidence map›Paper›PMID 31404636›Full record

ArticleResuscitation2019

Functional outcomes among survivors of pediatric in-hospital cardiac arrest are associated with baseline neurologic and functional status, but not with diastolic blood pressure during CPR.

Heather A Wolfe, Robert M Sutton, Ron W Reeder, Kathleen L Meert, Murray M Pollack, Andrew R Yates, John T Berger, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. [Paediatric Life Support].Notfall & rettungsmedizin · 2021
    Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 1 country.

Heather A WolfeDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA United States. Electronic address: wolfeh@email.chop.edu.
Robert M SuttonDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA United States.
Ron W ReederDepartment of Pediatrics, University of Utah, Salt Lake City, UT United States.
Kathleen L MeertDepartment of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI United States.
Murray M PollackDepartment of Pediatrics, Children's National Medical Center, Washington, D.C. United States; Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ United States.
Andrew R YatesDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH United States.
John T BergerDepartment of Pediatrics, Children's National Medical Center, Washington, D.C. United States.
Christopher J NewthDepartment of Anesthesiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA United States.
Joseph A CarcilloDepartment of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA United States.
Patrick S McQuillenDepartment of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA United States.
Rick E HarrisonDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA United States.
Frank W MolerDepartment of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, MI United States.
Todd C CarpenterDepartment of Pediatrics, Denver Children's Hospital, University of Colorado, Denver, CO United States.
Daniel A NottermanDepartment of Molecular Biology, Princeton University, Princeton, NJ United States.
Richard HolubkovDepartment of Pediatrics, University of Utah, Salt Lake City, UT United States.
J Michael DeanDepartment of Pediatrics, University of Utah, Salt Lake City, UT United States.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA United States.
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA United States.
Eunice Kennedy Shriver National Institute of Child Health
Human Development Collaborative Pediatric Critical Care Research Network
Pediatric Intensive Care Quality of Cardiopulmonary Resuscitation Investigators
Children's Hospital of Philadelphia · USUniversity of Utah · USChildren's National · USUniversity of Southern California · USChildren's Hospital Colorado · USNationwide Children's Hospital · USPrinceton University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of Pittsburgh · USWayne State University · US

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
Physiologically Guided Ventilator Strategies in ChildrenU10HD050012 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEWTH, CHRISTOPHER JOHN · 2005 to 2014
$3.7M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7M
Collaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Collaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaU10HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN · 2010 to 2014
$1.4M
Predicting Morbidity from Pediatric Critical CareU10HD063114 · NICHD · PHOENIX CHILDREN'S HOSPITAL · PI DALTON, HEIDI J, LUND, DENNIS P · 2010 to 2014
$1.4M
Collaborative Pediatric Research Critical Care Network(U10)U10HD063106 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2010 to 2014
$1.3M
NICHD NIH HHS RL1 HD107773NICHD NIH HHS U01 HD049934NICHD NIH HHS U10 HD050012NICHD NIH HHS U10 HD063106NICHD NIH HHS U10 HD063108NICHD NIH HHS U10 HD063114NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171
6 · The paper itself

Abstract

aimDiastolic blood pressure (DBP) during cardiopulmonary resuscitation (CPR) is associated with survival following pediatric in-hospital cardiac arrest. The relationship between intra-arrest haemodynamics and neurological status among survivors of pediatric cardiac arrest is unknown.

methodsThis study represents analysis of data from the prospective multicenter Pediatric Intensive Care Quality of cardiopulmonary resuscitation (PICqCPR) Study. Primary predictor variables were median DBP and median systolic blood pressure (SBP) over the first 10min of CPR. The primary outcome measure was "new substantive morbidity" determined by Functional Status Scale (FSS) and defined as an increase in the FSS of at least 3 points or increase of 2 in a single FSS domain. Univariable analyses were completed to investigate the relationship between new substantive morbidity and BPs during CPR.

results244 index CPR events occurred during the study period, 77 (32%) CPR events met all inclusion criteria as well as having both DBP and FSS data available. Among 77 survivors, 32 (42%) had new substantive morbidity as measured by the FSS score. No significant differences were identified in DBP (median 30.5mmHg vs. 30.9mmHg, p=0.5) or SBP (median 76.3mmHg vs. 63.0mmHg, p=0.2) between patients with and without new substantive morbidity. Children who developed new substantive morbidity were more likely to have lower pre-arrest FSS than those that did not (median [IQR]: 7.5 [6.0-9.0] versus 9.0 [7.0-13.0], p=0.01).

conclusionNew substantive morbidity determined by FSS after a pediatric IHCA was associated with baseline functional status, but not DBP during CPR.

Indexed as

Hospitals, PediatricAdolescentBlood PressureCardiopulmonary ResuscitationChildChild, PreschoolDiastoleFemaleFollow-Up StudiesHeart ArrestHospital MortalityHumansInfantInfant, NewbornMalePrognosisCardiac arrestCardiopulmonary resuscitation (CPR)In-hospitalOutcomesPediatricSurvival

Identifiers

PMID31404636
PMCPMC7050270
OpenAlexW2968617947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.