Evidence map›Paper›PMID 31404553›Full record

ArticleVision research2019

Effects of temporal frequency on binocular deficits in amblyopia.

Anna Kosovicheva, Adriana Ferreira, Fuensanta A Vera-Diaz, Peter J Bex

Open access · greenAbstract read
In one paragraph

Article in Vision research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Validation of Angular Indication Measurement (AIM) Stereoacuity.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Temporal Contour Integration Deficits in Children With Amblyopia.Investigative ophthalmology & visual science · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anna KosovichevaDepartment of Psychology, Northeastern University, 125 Nightingale Hall, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address: akosov@northeastern.edu.
Adriana FerreiraNew England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA.
Fuensanta A Vera-DiazNew England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA.
Peter J BexDepartment of Psychology, Northeastern University, 125 Nightingale Hall, 360 Huntington Avenue, Boston, MA 02115, USA.
New England College of Optometry · USNortheastern University · US

Funding

Efficient Assessment of Visual Deficits and Rehabilitation Methods in AmblyopiaR01EY021553 · NEI · OHIO STATE UNIVERSITY · PI LU, ZHONG-LIN · 2012 to 2016
$2.1M
Eye Movement Rehabilitation in Low Vision PatientsR01EY029713 · NEI · NORTHEASTERN UNIVERSITY · PI BEX, PETER JOHN · 2019 to 2023
$1.9M
SHORT TERM RES TRAINING AT THE NEW ENGLAND COLLEGE OFT35EY007149 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI Athanasios Panorgias · 1999 to 2026
$1.5M
Oculomotor deficits and plasticity across gaze posture in strabismusF32EY028814 · NEI · NORTHEASTERN UNIVERSITY · PI KOSOVICHEVA, ANNA · 2018 to 2020
$189k
NEI NIH HHS F32 EY028814NEI NIH HHS R01 EY021553NEI NIH HHS R01 EY029713NEI NIH HHS T35 EY007149
6 · The paper itself

Abstract

Amblyopia is associated with a range of well-known visual spatial deficits, which include reduced contrast sensitivity, spatial distortions, interocular suppression, and impaired stereopsis. Previous work has also pointed to deficits in processing dynamic visual information, but it is unknown whether these deficits influence performance under binocular conditions. We examined the effects of temporal modulation on contrast sensitivity and binocular interactions in a preliminary study of 8 adults with amblyopia and 14 normally-sighted control subjects. For each observer, we measured interocular balance and stereopsis thresholds with binocular flicker across a range of four temporal (0, 4, 7.5, and 12 Hz) and spatial (1, 2, 4, and 8 cpd) frequencies. Interocular balance was estimated by varying the relative contrast of dichoptic letter pairs to produce perceptual reports of each letter with equal frequency, and stereopsis thresholds were measured by determining the minimum disparity at which subjects identified a front-depth target with 75% accuracy. Consistent with previous findings, we observed greater interocular imbalance and impaired stereoacuity at high spatial frequencies in amblyopes. In contrast, the effects of temporal frequency on performance were smaller: across both groups, interocular imbalance was largest at mid-to-low temporal frequencies, and stereopsis thresholds were unaffected by temporal frequency. Our results suggest that there may be a previously unreported effect of temporal frequency on interocular balance, as well as a possible dissociation between the effects of flicker on interocular balance and stereopsis.

Indexed as

AdolescentAdultAmblyopiaContrast SensitivityDepth PerceptionFemaleHumansMaleMiddle AgedSensory ThresholdsVision, BinocularVisual AcuityYoung AdultAmblyopiaBinocularityFlickerStereopsisSuppressionTemporal contrast sensitivityTemporal frequency

Identifiers

PMID31404553
PMCPMC6726518
OpenAlexW2968783976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.