Trial reportAmerican journal of respiratory and critical care medicine2019
Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe Chronic Obstructive Pulmonary Disease (AIRFLOW). A Multicenter Randomized Controlled Clinical Trial.
Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Randomized Sham-controlled Trial of Targeted Lung Denervation in Patients with Chronic Obstructive Pulmonary Disease (AIRFLOW-3).American journal of respiratory and critical care medicine · 2025Trial
- Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease.European journal of medical research · 2023Trial
- Bronchial Rheoplasty for Treatment of Chronic Bronchitis. Twelve-Month Results from a Multicenter Clinical Trial.American journal of respiratory and critical care medicine · 2020Trial
- Two-Year Outcomes for the Double-Blind, Randomized, Sham-Controlled Study of Targeted Lung Denervation in Patients with Moderate to Severe COPD: AIRFLOW-2.International journal of chronic obstructive pulmonary disease · 2020Trial
- The Rise and Fall of Interventional Pulmonology Procedures: Lessons in Innovation, Evidence, and Abandonment.Diagnostics (Basel, Switzerland) · 2026Review
- A novel targeted lung denervation multi-polar radiofrequency ablation system for moderate to severe COPD patients: a translational study.Respiratory research · 2026Article
- Bronchoscopic endobronchial valves.Breathe (Sheffield, England) · 2026Review
- Targeted Lung Denervation in Chronic Obstructive Pulmonary Disease: Threading the Needle of Safe Interventions to Help the Sickest.American journal of respiratory and critical care medicine · 2025Article
- Autonomic nervous system dysfunction in chronic obstructive pulmonary disease: mechanistic insights and therapeutic implications.Annals of medicine · 2025Review
- A network of pro-inflammatory genes repressed by clock signalling in bronchial epithelium.ERJ open research · 2025Article
- Development and evaluation of an international teleproctoring program for bronchoscopic procedures.iScience · 2025Article
- Interventional pulmonology for chronic inflammatory airway diseases.Chinese medical journal pulmonary and critical care medicine · 2024Review
- ERJ Advances: interventional bronchoscopy.The European respiratory journal · 2024Article
- Review
- Bronchoscopic Management of COPD and Advances in Therapy.Life (Basel, Switzerland) · 2023Review
- Which Endoscopic Procedure to Use and in What Patient? Valves, Coils, Foam, and Heat in COPD and Asthma.Pulmonary therapy · 2023Review
- Modern Bronchoscopic Treatment Options for Patients with Chronic Bronchitis.Journal of clinical medicine · 2023Article
- Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD.ERJ open research · 2022Article
- Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.JACC. Basic to translational science · 2022Review
- ERS International Virtual Congress 2021: Highlights from the Turkish Thoracic Society Early Career Members.Turkish thoracic journal · 2022Article
Corrections and comments
- Commented on by
Authors and funding
22 authors at 14 institutions in 7 countries.
Dirk-Jan SlebosDepartment of Pulmonary Diseases and.
Pallav L ShahRoyal Brompton & Harefield NHS Trust, Chelsea & Westminster Hospital and Imperial College London, London, United Kingdom.ORCID 0000-0002-9052-4638
Felix J F HerthDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, and.
Christophe PisonCHU Grenoble Alpes, Service Universitaire Pneumologie Physiologie, Université Grenoble Alpes, Grenoble, France.
Christian SchumannClinic of Pneumology, Thoracic Oncology, Sleep and Respiratory Critical Care, Klinikverbund Kempten-Oberallgäu, Kempten and Immenstadt, Germany.
Ralf-Harto HübnerCharité Universitätsmedizin Berlin, Medizinische Klinik m. Schw. Infektiologie und Pneumologie, Campus Virchow, Berlin, Germany.
Peter I BontaDepartment of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Romain KesslerService de Pneumologie, Nouvel Hôpital Civil, Université de Strasbourg, Strasbourg, France.
Wolfgang GesierichAsklepios-Fachkliniken Munich-Gauting, Comprehensive Pneumology Center Munich, Gauting, Germany.
Kaid DarwicheDepartment of Pulmonary Medicine, Section of Interventional Pneumology, Ruhrlandklinik-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-0681-1325
Bernd LamprechtDepartment of Pulmonary Medicine, Kepler Universitatsklinikum GmbH, Linz, Austria.
Thierry PerezCHU de Lille-Hôpital Calmette, Lille, France.
Dirk SkowaschDepartment of Internal Medicine II-Cardiology/Pneumology, University of Bonn, Bonn, Germany.
Gaetan DesleeCHU de Reims, Hôpital Maison Blanche, Service de Pneumologie, Reims, France.
Armelle MarceauService de Pneumologie, Hôpital Universitaire Bichat, Paris, France.
Frank C SciurbaDepartment of Molecular Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Reinoud GosensUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
Jorine E HartmanDepartment of Pulmonary Diseases and.
Karthi SrikanthanRoyal Brompton & Harefield NHS Trust, Chelsea & Westminster Hospital and Imperial College London, London, United Kingdom.
Marina DullerDepartment of Respiratory and Critical Care Medicine, Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Krankenhaus Nord-Klinik Floridsdorf, Vienna, Austria.
Arschang ValipourDepartment of Respiratory and Critical Care Medicine, Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Krankenhaus Nord-Klinik Floridsdorf, Vienna, Austria.
AIRFLOW-2 Study Group
University Medical Center Groningen · NLAmsterdam UMC Location University of Amsterdam · NLChelsea and Westminster Hospital · GBMinneapolis Institute of Arts · USRuhrlandklinik · DEUniversity of Bonn · DEAsklepios Fachkliniken München-Gauting · DECentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Reims · FRHeidelberg University · DEKarl Landsteiner Society · ATOtto Wagner Hospital · ATUniversity of Pittsburgh · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
BronchoscopyDenervationRadiofrequency AblationAgedBronchodilator AgentsDouble-Blind MethodFemaleForced Expiratory VolumeHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveTreatment OutcomeBronchodilator Agentsanticholinergicbronchoscopychronic obstructive pulmonary diseasenervestargeted lung denervation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.