Evidence map›Paper›PMID 31404454›Full record

ArticleJournal of molecular biochemistry2019

Stress Management in Women with Hashimoto's thyroiditis: A Randomized Controlled Trial.

Zoe S Markomanolaki, Xanthi Tigani, Thomas Siamatras, Flora Bacopoulou, Athanasios Tsartsalis, Artemios Artemiadis, Vasileios Megalooikonomou, Dimitrios Vlachakis, George P Chrousos, Christina Darviri

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of molecular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zoe S MarkomanolakiPostgraduate Course of Stress Management and Health Promotion, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Xanthi TiganiPostgraduate Course of Stress Management and Health Promotion, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Thomas SiamatrasNaval Hospital of Athens, Greece.
Flora BacopoulouCenter for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens 11527, Greece.
Athanasios TsartsalisNaval Hospital of Athens, Greece.
Artemios ArtemiadisPostgraduate Course of Stress Management and Health Promotion, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Vasileios MegalooikonomouComputer Engineering and Informatics Department, School of Engineering, University of Patras, Patras 26500, Greece.
Dimitrios VlachakisLaboratory of Genetics, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 75 Iera Odos, 11855, Athens, Greece.
George P ChrousosPostgraduate Course of Stress Management and Health Promotion, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Christina DarviriPostgraduate Course of Stress Management and Health Promotion, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Athens Naval & Veterans Hospital · GRNational and Kapodistrian University of Athens · GRAcademy of Athens · GRUniversity of Patras · GR

Funding

Large Scale Data Analysis for Brain ImagesR01MH068066 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI MEGALOOIKONOMOU, VASILEIOS · 2004 to 2007
$1.3M
NIMH NIH HHS R01 MH068066
6 · The paper itself

Abstract

aimStress has been implicated in the pathogenesis of Hashimoto's thyroiditis (HT), nevertheless evidence is scarce regarding the effect of stress management on individuals suffering from HT. The purpose of this study was to evaluate the impact of an 8-week stress management intervention on the anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies as well as thyroid-stimulating hormone (TSH) levels of women with HT. Secondary endpoints included the effect on the patients' lifestyle, body mass index (BMI), depression, anxiety and stress.

methodsThis was a two-arm parallel group (stress management intervention vs. standard care groups) randomized controlled study. Adult women with Hashimoto's thyroiditis, completed questionnaires on stress, anxiety, depression and lifestyle, at the beginning of the programme and 8 weeks later. Laboratory thyroid function tests (anti-TPO, anti-TG antibodies and TSH) were also measured at baseline and at the end of the study.

resultsA total of 60 women with HT, aged 25-76 years, participated in the study (30 patients in each group). After eight weeks, patients in the intervention group demonstrated statistically significant beneficial decrements in the rate change of anti-TG titers and the levels of stress, depression and anxiety as well as better lifestyle scores, compared to the control group.

Identifiers

PMID31404454
PMCPMC6688766
OpenAlexW2966598555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.