Evidence map›Paper›PMID 31404388›Full record

ArticleComparative cytogenetics2019

Dysfunction telomeres in embryonic fibroblasts and cultured

Natalya S Zhdanova, Evgenia A Vaskova, Tatyana V Karamysheva, Julia M Minina, Nykolay B Rubtsov, Suren M Zakian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative cytogenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natalya S ZhdanovaThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.
Evgenia A VaskovaThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.
Tatyana V KaramyshevaThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.
Julia M MininaThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.ORCID https://orcid.org/0000-0003-1504-9803
Nykolay B RubtsovThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.
Suren M ZakianThe Federal Research Center Institute of Cytology and Genetics SB RAS, Acad. Lavrentiev Ave. 10, Novosibirsk 630090, Russia The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia.
Institute of Cytology and Genetics · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the level of spontaneous telomere dysfunction in Rattus norvegicus (Berkenhout, 1769) (Rodentia, Muridae) embryonic fibroblasts (rEFs) and in cultured in vitro rat pluripotent stem cells (rPSCs), embryonic stem cells (rESCs) and induced pluripotent stem cells (riPSCs), on early passages and after prolonged cultivation. Among studied cell lines, rESCs showed the lowest level of telomere dysfunction, while the riPSCs demonstrated an elevated level on early passages of cultivation. In cultivation, the frequency of dysfunctional telomeres has increased in all studied cell lines; this is particularly true for dysfunctional telomeres occurring in G1 stage in riPSCs. The obtained data are mainly discussed in the connection with the specific structure of the telomere regions and their influence on the differential DNA damage response in them.

Indexed as

dysfunctional telomeresembryonic fibroblastsESCiPSCrat

Identifiers

PMID31404388
PMCPMC6684521
OpenAlexW2965510054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.