Evidence map›Paper›PMID 31404153›Full record

ArticleFrontiers in neuroscience2019

Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

Li Lin, Li Juan Zheng, U Joseph Schoepf, Akos Varga-Szemes, Rock H Savage, Yun Fei Wang, Han Zhang, Xin Yuan Zhang, Guang Ming Lu, Long Jiang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Li LinDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Li Juan ZhengDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
U Joseph SchoepfDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Akos Varga-SzemesDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States.
Rock H SavageDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States.
Yun Fei WangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Han ZhangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Xin Yuan ZhangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Guang Ming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Long Jiang ZhangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Nanjing General Hospital of Nanjing Military Command · CNNanjing Medical University · CNMedical University of South Carolina · USNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI).

methodsWe prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level in different states of disease. The amplitude of low-frequency fluctuation (ALFF) method was applied to assess spontaneous brain activity among groups. Pearson's correlation analysis was used to investigate the relationships between the mean ALFF values (mALFF) and cognitive tests.

resultsA total of 97 patients completed the study protocol successfully. Significant differences in age, education level, number connection test (NCT), and word fluency were observed among the three subgroups in males (all

conclusionOur results suggest that elevated SUA levels have different effects on spontaneous brain activities and cognitive function in males and females. Males with pre-hyperuricemia and hyperuricemia are more susceptible to changes in spontaneous brain activities and lower neuropsychological assessment scores, particularly in word fluency tests and NCT, compared to females.

Indexed as

amplitude of low-frequency fluctuationblood oxygen level dependentcognitive functionresting-stage functional magnetic resonance imaginguric acid

Identifiers

PMID31404153
PMCPMC6676594
OpenAlexW2957960931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.