Evidence map›Paper›PMID 31404104›Full record

Trial reportPloS one2019

Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients.

Naho Ihara, Kenta Wakaizumi, Daisuke Nishimura, Jungo Kato, Takashige Yamada, Takeshi Suzuki, Saori Hashiguchi, Yuri Terasawa, Shizuko Kosugi, Hiroshi Morisaki

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naho IharaDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Kenta WakaizumiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Daisuke NishimuraDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Jungo KatoDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Takashige YamadaDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Takeshi SuzukiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Saori HashiguchiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Yuri TerasawaDepartment of Psychology, Keio University, Tokyo, Japan.
Shizuko KosugiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-1246-8594
Hiroshi MorisakiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.

Indexed as

Chronic PainConnectomeMagnetic Resonance ImagingNeck PainNeural PathwaysPrefrontal CortexAdultFemaleHumansMaleMiddle Aged

Identifiers

PMID31404104
PMCPMC6690512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.