Evidence map›Paper›PMID 31403778›Full record

ReviewJournal of the American Chemical Society2019

Advancing Solutions to the Carbohydrate Sequencing Challenge.

Christopher J Gray, Lukasz G Migas, Perdita E Barran, Kevin Pagel, Peter H Seeberger, Claire E Eyers, Geert-Jan Boons, Nicola L B Pohl, Isabelle Compagnon, Göran Widmalm and 1 more

Abstract readReview
In one paragraph

Review in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Article
  2. Automating Model Building for SPM Images of Biomolecules Using MISO.Journal of chemical information and modeling · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher J GraySchool of Chemistry & Manchester Institute of Biotechnology , The University of Manchester , 131 Princess Street , Manchester M1 7DN , U.K.
Lukasz G MigasSchool of Chemistry & Manchester Institute of Biotechnology , The University of Manchester , 131 Princess Street , Manchester M1 7DN , U.K.
Perdita E BarranSchool of Chemistry & Manchester Institute of Biotechnology , The University of Manchester , 131 Princess Street , Manchester M1 7DN , U.K.ORCID 0000-0002-7720-586X
Kevin PagelInstitute for Chemistry and Biochemistry , Freie Universität Berlin , Takustraße 3 , 14195 Berlin , Germany.ORCID 0000-0001-8054-4718
Peter H SeebergerBiomolecular Systems Department , Max Planck Institute for Colloids and Interfaces , Am Muehlenberg 1 , 14476 Potsdam , Germany.ORCID 0000-0003-3394-8466
Claire E EyersDepartment of Biochemistry, Institute of Integrative Biology , University of Liverpool , Crown Street , Liverpool L69 7ZB , U.K.
Geert-Jan BoonsComplex Carbohydrate Research Center , University of Georgia , Athens , Georgia 30602 , United States.ORCID 0000-0003-3111-5954
Nicola L B PohlDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.ORCID 0000-0001-7747-8983
Isabelle CompagnonInstitut Lumière Matière, UMR5306 Université Lyon 1-CNRS , Université de Lyon , 69622 Villeurbanne Cedex , France.ORCID 0000-0003-2994-3961
Göran WidmalmDepartment of Organic Chemistry, Arrhenius Laboratory , Stockholm University , S-106 91 Stockholm , Sweden.ORCID 0000-0001-8303-4481
Sabine L FlitschSchool of Chemistry & Manchester Institute of Biotechnology , The University of Manchester , 131 Princess Street , Manchester M1 7DN , U.K.ORCID 0000-0003-3974-646X

Funding

Sugar Building Blocks and Automated Synthesis of Biomedically-Relevant GlycansU01GM116248 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI POHL, NICOLA L. B. · 2015 to 2019
$2.7M
Biotechnology and Biological Sciences Research Council BB/L013762/1Biotechnology and Biological Sciences Research Council BB/M027791/1Biotechnology and Biological Sciences Research Council BB/M028836/1Biotechnology and Biological Sciences Research Council BB/M02903411NIGMS NIH HHS U01 GM116248
6 · The paper itself

Abstract

Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.

Indexed as

CarbohydratesCarbohydrate SequenceSpectrum AnalysisStructure-Activity RelationshipCarbohydrates

Identifiers

PMID31403778
PMCPMC9397603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.