ArticleMolecular microbiology2019
Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans.
Article in Molecular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Quorum sensing in streptococci and its peptide-mediated modulation.Bioscience reports · 2026Review
- Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci.F1000Research · 2026Review
- Article
- Unveiling the regulatory network controlling natural transformation in lactococci.PLoS genetics · 2024Article
- Identification of a Novel Gene Involved in Cell-to-cell Communication-induced Cell Death and eDNA Production in Streptococcus mutans.Microbes and environments · 2023Article
- Article
- Expanding natural transformation to improve beneficial lactic acid bacteria.FEMS microbiology reviews · 2022Article
- Clp ATPases differentially affect natural competence development in Streptococcus mutans.MicrobiologyOpen · 2022Article
- Competence shut-off by intracellular pheromone degradation in salivarius streptococci.PLoS genetics · 2022Article
- Article
- Article
- A Novel Competence Pathway in the Oral PathogenJournal of dental research · 2021Article
- Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.Nature microbiology · 2021Article
- Direct interactions with commensal streptococci modify intercellular communication behaviors of Streptococcus mutans.The ISME journal · 2021Article
- Article
- Spatial Correlations and Distribution of Competence Gene Expression in Biofilms ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In Streptococcus mutans, the alternative sigma factor ComX controls entry into genetic competence. Competence stimulating peptide (CSP) induces bimodal expression of comX, with only a fraction of the population becoming transformable. Curiously, the bimodality of comX is affected by peptides in the growth medium and by carbohydrate source. CSP elicits bimodal expression of comX in media rich in small peptides, but CSP elicits no response in defined media lacking small peptides. In addition, growth on certain sugars increases the proportion of the population that activates comX in response to CSP. By investigating the connection between media and comX bimodality, we find evidence for two mechanisms that modulate transcriptional positive feedback in the ComRS system, where comX bimodality originates. We find that the endopeptidase PepO suppresses the ComRS feedback loop, most likely by degrading the XIP/ComS feedback signal. Deletion of pepO eliminates comX bimodality, leading to a unimodal comX response to CSP in both defined and complex media. We also find that CSP stimulates the ComRS feedback system by upregulating comR in a carbohydrate source-dependent fashion. Our data provide mechanistic insight into how S. mutans regulates bimodality and explain the puzzle of growth medium effects on competence induction by CSP.
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Registered trials
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