Evidence map›Paper›PMID 31403412›Full record

ArticleIEEE transactions on image processing : a publication of the IEEE Signal Processing Society2019

Multiresolution Localization with Temporal Scanning for Super-Resolution Diffuse Optical Imaging of Fluorescence.

Brian Z Bentz, Dergan Lin, Justin A Patel, Kevin J Webb

Open access · hybridAbstract read
In one paragraph

Article in IEEE transactions on image processing : a publication of the IEEE Signal Processing Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brian Z Bentz
Dergan Lin
Justin A Patel
Kevin J Webb
Purdue University West Lafayette · USSandia National Laboratories · US

Funding

In Vivo Optical Imaging of Alpha-Synuclein AggregationR21NS105048 · NINDS · PURDUE UNIVERSITY · PI WEBB, KEVIN J · 2018 to 2019
$403k
Optical Imaging of Targeted Anti-Cancer Drug Delivery KineticsR21CA182235 · NCI · PURDUE UNIVERSITY · PI WEBB, KEVIN J · 2015 to 2016
$368k
NCI NIH HHS R21 CA182235NINDS NIH HHS R21 NS105048
6 · The paper itself

Abstract

A super-resolution optical imaging method is presented that relies on the distinct temporal information associated with each fluorescent optical reporter to determine its spatial position to high precision with measurements of heavily scattered light. This multiple-emitter localization approach uses a diffusion equation forward model in a cost function, and has the potential to achieve micron-scale spatial resolution through centimeters of tissue. Utilizing some degree of temporal separation for the reporter emissions, position and emission strength are determined using a computationally efficient time stripping multiresolution algorithm. The approach circumvents the spatial resolution challenges faced by earlier optical imaging approaches using a diffusion equation forward model, and is promising for in vivo applications. For example, in principle, the method could be used to localize individual neurons firing throughout a rodent brain, enabling direct imaging of neural network activity.

Identifiers

PMID31403412
PMCPMC7012689
OpenAlexW2969038981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.