Evidence map›Paper›PMID 31403352›Full record

ArticleHuman vaccines & immunotherapeutics2020

Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in

Zhijian Yang, Fan Gao, Xiaoliang Wang, Likang Shi, Zheng Zhou, Yuanxiang Jiang, Xinxing Ma, Chao Zhang, Chenliang Zhou, Xianfang Zeng and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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  8. Current status of hand-foot-and-mouth disease.Journal of biomedical science · 2023
    Review
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  12. A practical method for evaluating theEmerging microbes & infections · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Zhijian YangShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.ORCID 0000-0002-5143-0890
Fan GaoDivision of Hepatitis Virus Vaccines, National Institutes for Food and Drug Control (NIFDC) , Beijing, PR China.
Xiaoliang WangShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Likang ShiShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Zheng ZhouShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Yuanxiang JiangShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Xinxing MaShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Chao ZhangShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Chenliang ZhouShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Xianfang ZengShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Ge LiuShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Jiang FanShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
Qunying MaoDivision of Hepatitis Virus Vaccines, National Institutes for Food and Drug Control (NIFDC) , Beijing, PR China.
Li ShiShanghai Zerun Biotechnology Co., Ltd , Shanghai, PR China.
National Institutes for Food and Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus 71 (EV71) is one of the major causative agents for hand, foot and mouth disease (HFMD) in children. Although there are three inactivated virus-based HFMD vaccines licensed in China, alternative approaches have been taken to produce an effective and safer vaccine that is easier to manufacture in large scale. Among these, a virus-like particles (VLPs) based EV71 vaccine is under active development. For this purpose, an efficient methodology for the production of EV71-VLPs by recombinant technology is needed. We here report the construction and expression of the P1 and 3C genes of EV71 in

Indexed as

EnterovirusEnterovirus A, HumanHand, Foot and Mouth DiseaseVaccines, Virus-Like ParticleViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralChinaMiceSaccharomycetalesAntibodies, NeutralizingAntibodies, ViralVaccines, Virus-Like ParticleViral VaccinesEnterovirus 71hand foot and mouth diseaseimmunogenicityPichia pastorisvaccinevirus-like particles

Identifiers

PMID31403352
PMCPMC7482752
OpenAlexW2967746812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.