ArticleHuman brain mapping2019
Patterns of co-altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- Relationships between early age at onset of psychotic symptoms and treatment resistant schizophrenia.Early intervention in psychiatry · 2022Trial
- Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- Fusion analysis of sMRI-DTI in patients with ulcerative colitis by multimodal CCA + joint ICA and associated neurotransmitter profiles.BMC medicine · 2025Article
- Sensori- and psychomotor abnormalities, psychopathological symptoms and functionality in schizophrenia-spectrum disorders: a network analytic approach.Schizophrenia (Heidelberg, Germany) · 2025Article
- Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- Neurological Soft Signs in Schizophrenia, a Picture of the Knowledge in the Last Decade: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter.Frontiers in neurology · 2023Article
- A tablet-based quantitative assessment of manual dexterity for detection of early psychosis.Frontiers in psychiatry · 2023Article
- Parkinson's Disease-Related Brain Metabolic Pattern Is Expressed in Schizophrenia Patients during Neuroleptic Drug-Induced Parkinsonism.Diagnostics (Basel, Switzerland) · 2022Article
- The neural substrates of neurological soft signs in schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2022Review
- Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia.Schizophrenia bulletin · 2022Article
- Neurological Soft Signs Predict Auditory Verbal Hallucinations in Patients With Schizophrenia.Schizophrenia bulletin · 2021Article
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
- Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study.Schizophrenia bulletin · 2021Article
- Neurological Soft Signs (NSS) in Census-Based, Decade-Adjusted Healthy Adults, 20 to >70 Years of Age.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co-altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right-handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data-multiset canonical correlation and joint independent component analysis (mCCA + jICA)-to investigate co-altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group-discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality-specific group-discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.
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