ArticleMaxillofacial plastic and reconstructive surgery2019
Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw.
Article in Maxillofacial plastic and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dental Implant Survival and Risk of Medication-Related Osteonecrosis in the Jaws in Patients Undergoing Antiresorptive Therapy: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Clinical and Epidemiological Characteristics of Retrospective Single-Center Observational Study.Journal of clinical medicine · 2026Article
- Clinical and Histopathological Aspects of MRONJ in Cancer Patients.Journal of clinical medicine · 2023Article
- Multiple ways for the same destination: bone regeneration.Maxillofacial plastic and reconstructive surgery · 2022Review
- How do specialist surgeons treat the atrophic tooth gap? A vignette-based study among maxillofacial and oral surgeons.BMC oral health · 2021Article
- Various Therapeutic Methods for the Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) and Their Limitations: A Narrative Review on New Molecular and Cellular Therapeutic Approaches.Antioxidants (Basel, Switzerland) · 2021Review
- The role of antiresorptive drugs and medication-related osteonecrosis of the jaw in nononcologic immunosuppressed patients: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- Gradual, but Not Sudden, Dose-Dependent Increase of ONJ Risk With Bisphosphonate Exposure: A Nationwide Cohort Study in Women With Osteoporosis.Frontiers in endocrinology · 2021Article
- Immunomodulation for maxillofacial reconstructive surgery.Maxillofacial plastic and reconstructive surgery · 2020Review
- Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.International journal of molecular sciences · 2020Article
- In vitro effects of alendronate on fibroblasts of the human rotator cuff tendon.BMC musculoskeletal disorders · 2020Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate clinical and pharmacoepidemiologic characteristics of medication-related osteonecrosis of the jaw.
methodsThe study population is comprised of 86patients who were diagnosed with ONJ at Ewha Womans University Mokdong Hospital from 2008 to 2015. Factors for epidemiologic evaluation were gender, age, location of lesion, and clinical history. The types of bisphosphonates, duration of intake, and the amount of accumulated dose were evaluated for therapeutic response. Clinical symptoms and radiographic images were utilized for the assessment of prognosis.
resultsAmong the 86 patients, five were male, whereas 81 were female with mean age of 73.98 (range 45-97). Location of the lesion was in the mandible for 58 patients and maxilla in 25 patients. Three patients had both mandible and maxilla affected. This shows that the mandible is more prone to the formation of ONJ lesions compared to the maxilla. ONJ occurred in 38 cases after extraction, nine cases after implant surgery, six cases were denture use, and spontaneously in 33 cases. Seventy-six patients were taking other drugs aside from drugs indicated for osteoporosis. Most of these patients were diagnosed as osteoporosis, rheumatic arthritis, multiple myeloma, or had a history of cancer therapy. Higher weighted total accumulation doses were significantly associated with poorer prognosis (
conclusionDose, duration, route, and relative potency of bisphosphonates are significantly associated with treatment prognosis of osteonecrosis of the jaw.
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