ArticleEvolution, medicine, and public health2019
Iron and fecundity among Tsimane' women of Bolivia.
Article in Evolution, medicine, and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 13 citations in OpenAlex.
- Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Low haemoglobin in arduous seasons is associated with reduced chance of ovulation among women living in the BolivianEvolution, medicine, and public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIron is critical for women's reproduction, and iron-deficiency anemia is a global health problem for mothers. While public health programs have aimed to correct iron deficiency in reproductive-aged women with supplementation, a small group of studies have shown that too much iron also has negative effects on birth outcomes. We hypothesize that women's iron levels evolved within a narrow optimum, and predict that hemoglobin (Hb) levels would be associated with women's fecundity. METHODOLOGY: We used the publicly available, longitudinal Tsimane' Amazonian Panel Study to test the association between -Hb levels and hazard of having a next birth (a measure of fecundity) among 116 parous, reproductive-aged Tsimane' women of Bolivia. A Cox proportional hazards model was used to model Hb level and other predictors against the event of next birth across the observation period, which began at each woman's previous birth.
resultsThe higher the Hb level, the lower the hazard of a woman giving birth within the study observation period (hazard ratio=0.82, CONCLUSIONS AND IMPLICATIONS: These results demonstrate that high Hb influences women's fecundity. These results supports the growing body of literature showing that iron metabolism is critical for understanding the evolution of women's reproduction. More work is needed to determine the evolved optimal range of iron levels for reproductive-aged women. LAY SUMMARY: Lower chance of pregnancy among Tsimane' women with high Hb levels, suggesting evolved optimal Hb levels in women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.