Evidence map›Paper›PMID 31402931›Full record

ReviewDrugs in context2019

New uses and formulations of glucagon for hypoglycaemia.

Pilar I Beato-Víbora, Francisco J Arroyo-Díez

Open access · goldAbstract readReview
In one paragraph

Review in Drugs in context, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Dasiglucagon: an effective medicine for severe hypoglycemia.European journal of clinical pharmacology · 2021
    Review
  12. Review
  13. Proglucagon-Derived Peptides as Therapeutics.Frontiers in endocrinology · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pilar I Beato-VíboraDepartment of Endocrinology and Nutrition, Department of Paediatrics, Badajoz University Hospital, Badajoz, Spain.
Francisco J Arroyo-DíezDepartment of Endocrinology and Nutrition, Department of Paediatrics, Badajoz University Hospital, Badajoz, Spain.
Centro de Implantología Cirugía Oral y Maxilofacial · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoglycaemia is the more frequent complication of insulin therapy and the main barrier to tight glycaemic control. Injectable glucagon and oral intake of carbohydrates are the recommended treatments for severe and non-severe hypoglycaemia episodes, respectively. Nasal glucagon is currently being developed as a ready-to-use device, to simplify severe hypoglycaemia rescue. Stable forms of liquid glucagon could open the field for different approaches for mild to moderate hypoglycaemia treatment, such as mini-doses of glucagon or continuous subcutaneous glucagon infusion as a part of dual-hormone closed-loop systems. Pharmaceutical companies are developing stable forms of native glucagon or glucagon analogues for that purpose.

Indexed as

dual-hormone artificial pancreasexerciseglucagonhypoglycaemiainjectable glucagonmini-dose glucagonnasal glucagontype 1 diabetes

Identifiers

PMID31402931
PMCPMC6675539
OpenAlexW2965935454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.