Evidence map›Paper›PMID 31402630›Full record

ArticleAnnals of clinical and translational neurology2019

Early ictal recruitment of midline thalamus in mesial temporal lobe epilepsy.

Andrew Romeo, Alexandra T Issa Roach, Emilia Toth, Ganne Chaitanya, Adeel Ilyas, Kristen O Riley, Sandipan Pati

Open access · goldAbstract readCase Reports
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults.Annals of clinical and translational neurology · 2026
    Pooled it
  2. Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
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  13. Causal Cortical and Thalamic Connections in the Human Brain.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew RomeoDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama.
Alexandra T Issa RoachDepartment of Neurology, University of Alabama at Birmingham, Alabama.
Emilia TothDepartment of Neurology, University of Alabama at Birmingham, Alabama.
Ganne ChaitanyaDepartment of Neurology, University of Alabama at Birmingham, Alabama.
Adeel IlyasDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama.
Kristen O RileyDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama.
Sandipan PatiDepartment of Neurology, University of Alabama at Birmingham, Alabama.ORCID 0000-0002-9578-2820
University of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 sec) and propagation (9-60 sec). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure-induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.

Indexed as

AdultElectric StimulationElectroencephalographyEpilepsy, Temporal LobeEvoked PotentialsHippocampusHumansSeizuresThalamus

Identifiers

PMID31402630
PMCPMC6689686
OpenAlexW2953796149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.