Evidence map›Paper›PMID 31402589›Full record

ReviewAdvanced healthcare materials2019

Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications.

Kamil Elkhoury, Carina S Russell, Laura Sanchez-Gonzalez, Azadeh Mostafavi, Tyrell J Williams, Cyril Kahn, Nicholas A Peppas, Elmira Arab-Tehrany, Ali Tamayol

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kamil ElkhouryLIBio, Université de Lorraine, F-54000, Nancy, France.
Carina S RussellDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.
Laura Sanchez-GonzalezLIBio, Université de Lorraine, F-54000, Nancy, France.
Azadeh MostafaviDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.
Tyrell J WilliamsDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.
Cyril KahnLIBio, Université de Lorraine, F-54000, Nancy, France.
Nicholas A PeppasDepartments of Biomedical and Chemical Engineering, Departments of Pediatrics and Surgery, Dell Medical School, University of Texas at Austin, Austin, TX, 78712, USA.
Elmira Arab-TehranyLIBio, Université de Lorraine, F-54000, Nancy, France.
Ali TamayolDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.ORCID 0000-0003-1801-2889

Funding

Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle lossR01AR073822 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI TAMAYOL, ALI · 2018 to 2022
$1.8M
Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
Ministry of Higher EducationNebraska Tobacco Settlement Biomedical Research Enhancement FundsNIAMS NIH HHS R01 AR073822NIBIB NIH HHS R01 EB022025NIGMS NIH HHS R01 GM126831NIH HHS U54-143837-02University of Nebraska-Lincoln
6 · The paper itself

Abstract

Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

Indexed as

AnimalsGene Transfer TechniquesHumansHydrogelsNanoparticlesPolymersSignal TransductionTissue EngineeringHydrogelsPolymersnanofunctionalizationnatural hydrogelssoft nanoparticlestissue engineering

Identifiers

PMID31402589
PMCPMC6752977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.