Evidence map›Paper›PMID 31402541›Full record

ArticleJournal of cellular and molecular medicine2019

Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation.

Fabian Emrich, Kiril Penov, Mamoru Arakawa, Nathan Dhablania, Grayson Burdon, Albert J Pedroza, Tiffany K Koyano, Young M Kim, Uwe Raaz, Andrew J Connolly and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Fabian EmrichDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Kiril PenovDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Mamoru ArakawaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Nathan DhablaniaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Grayson BurdonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Albert J PedrozaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Tiffany K KoyanoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.
Young M KimDepartment of Cardiovascular Medicine, Stanford University, Stanford, California.
Uwe RaazDepartment of Cardiovascular Medicine, Stanford University, Stanford, California.
Andrew J ConnollyDepartment of Pathology, Stanford University, Stanford, California.
Cristiana IosefDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.ORCID 0000-0002-0535-8605
Michael P FischbeinDepartment of Cardiothoracic Surgery, Stanford University, Stanford, California.ORCID 0000-0002-0638-2025
Stanford University · USCardiovascular Institute of the South · USLeipzig Heart Institute · DEJichi Medical University · JP

Funding

Marfan Aortic Embryologic Origin Influences miR-29b Regulators and TargetsR01AR066629 · NIAMS · STANFORD UNIVERSITY · PI FISCHBEIN, MICHAEL PETER · 2016 to 2020
$1.5M
NIAMS NIH HHS R01 AR066629
6 · The paper itself

Abstract

Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root aneurysm formation. Reactive oxygen species (ROS) seem to play a role in aortic wall remodelling in MFS, although the mechanism remains unknown. MFS Fbn1

Indexed as

AcetophenonesAneurysmAngiotensin IIAnimalsAortaDisease Models, AnimalFibrillin-1Marfan SyndromeMice, Inbred C57BLMyocytes, Smooth MuscleNADPH OxidasesReactive Oxygen SpeciesAcetophenonesacetovanilloneAngiotensin IIFibrillin-1NADPH OxidasesReactive Oxygen SpeciesaneurysmMarfan syndromereactive oxygen species

Identifiers

PMID31402541
PMCPMC6787454
OpenAlexW2967468194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.