Evidence map›Paper›PMID 31402512›Full record

ArticleMagnetic resonance in medicine2020

High-resolution intravascular MRI-guided perivascular ultrasound ablation.

Xiaoyang Liu, Nicholas Ellens, Emery Williams, Everette C Burdette, Parag Karmarkar, Clifford R Weiss, Dara Kraitchman, Paul A Bottomley

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaoyang LiuDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-5969-1390
Nicholas EllensDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Emery WilliamsAcoustic MedSystems, Inc, Champaign, Illinois.
Everette C BurdetteAcoustic MedSystems, Inc, Champaign, Illinois.
Parag KarmarkarDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Clifford R WeissDivision of Interventional Radiology, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Dara KraitchmanDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Paul A BottomleyDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USAcoustic MedSystems (United States) · US

Funding

Advanced MRI Technology in Safety & InterventionR01EB007829 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BOTTOMLEY, PAUL A · 2008 to 2017
$4.3M
NIBIB NIH HHS R01 EB007829
6 · The paper itself

Abstract

purposeTo develop and test in animal studies ex vivo and in vivo, an intravascular (IV) MRI-guided high-intensity focused ultrasound (HIFU) ablation method for targeting perivascular pathology with minimal injury to the vessel wall.

methodsIV-MRI antennas were combined with 2- to 4-mm diameter water-cooled IV-ultrasound ablation catheters for IV-MRI on a 3T clinical MRI scanner. A software interface was developed for monitoring thermal dose with real-time MRI thermometry, and an MRI-guided ablation protocol developed by repeat testing on muscle and liver tissue ex vivo. MRI thermal dose was measured as cumulative equivalent minutes at 43°C (CEM

resultsEx vivo experiments yielded a 6-min ablation protocol with the IV-ultrasound catheter coolant at 3-4°C, a 30 mL/min flow rate, and 7 W ablation power. In 8 experiments, 5- to 10-mm thick thermal lesions of area 0.5-2 cm

conclusionIV-MRI-guided, IV-HIFU has potential as a precision treatment option that could preserve critical blood vessel wall during ablation of nonresectable perivascular tumors or other pathologies.

Indexed as

High-Intensity Focused Ultrasound AblationMagnetic Resonance ImagingAnimalsBlood VesselsChickensIn Vitro TechniquesLiverMuscle, SkeletalPsoas MusclesSwineTemperatureThermometryVena Cava, Inferiorhigh intensity focused ultrasound (HIFU)intravascular MRI (IVMRI)liver and pancreatic cancerMR-guided ultrasound ablationvessel involvement

Identifiers

PMID31402512
PMCPMC6778713
OpenAlexW2968335076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.