ArticleNeurourology and urodynamics2019
Abnormal vaginal microbiome associated with vaginal mesh complications.
Article in Neurourology and urodynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The Study of Microbiome of the Female Genital Area in Relation to Pelvic Floor Dysfunction: A Systematic Review.International urogynecology journal · 2024Pooled it
- Vaginal Microbiota and Pelvic Floor Dysfunction: Mechanistic Insights and Therapeutic Implications.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Genome sequence ofMicrobiology resource announcements · 2026Article
- Association of Preoperative Inflammatory and Immune Markers with Mesh Exposure After Transvaginal Mesh Surgery for Pelvic Organ Prolapse.International urogynecology journal · 2026Article
- Distinct microbiome profiles on vaginally inserted polypropylene midurethral mesh slings compared to vaginal, urinary, and skin microbiomes.Applied and environmental microbiology · 2025Article
- Polypropylene Pelvic Mesh: What Went Wrong and What Will Be of the Future?Biomedicines · 2023Review
- Host-biomaterial interactions in mesh complications after pelvic floor reconstructive surgery.Nature reviews. Urology · 2021Review
- Actinomyces in explanted transvaginal mesh: commensal or pathogen?International urogynecology journal · 2021Article
- Reoperation rate and outcomes following the placement of polypropylene mesh by the vaginal route for cystocele: very long-term follow-up.International urogynecology journal · 2021Article
- The international discussion and the new regulations concerning transvaginal mesh implants in pelvic organ prolapse surgery.International urogynecology journal · 2020Review
- Abnormal vaginal microbiome associated with vaginal mesh complications.Neurourology and urodynamics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo identify differences in the vaginal microbiomes of women after transvaginal mesh (TVM) surgery for pelvic organ prolapse with and without mesh-associated complications.
methodsPatients with complications were eligible as cases, patients without as controls. DNA was isolated and the V1-2 region of the 16S ribosomal RNA gene was amplified and sequenced. Overall richness was quantified using Chao1. Overall diversity was expressed as Shannon diversity and screened for group differences using analysis of variance. Multivariate differences among groups were evaluated with functions from R.
resultsWe recruited 14 patients after mesh exposure, 5 after contraction, and 21 as controls. The average number of operational taxonomic unit was 74.79 (SD ± 63.91) for controls, 57.13 (SD ± 58.74) after exposures, and 92.42 (SD ± 50.01) after contractions. Total 89.6% of bacteria in controls, 86.4% in previous exposures, and 81.3% in contractions were classified as either Firmicutes, Proteobacteria, or Actinobacteria (P < .001). Veillonella spp. was more abundant in patients after contraction (P = .045). The individual microbiomes varied, and we did not detect any significant differences in richness but a trend towards higher diversity with complications.
conclusionsThe presence of Veillonella spp. could be associated with mesh contraction. Our study did not identify vaginal microbiotic dysbiosis as a factor associated with exposure. Larger cohort studies would be needed to distinguish the vaginal microbiome of women predisposed to mesh-related complications for targeted phenotyping of patients who could benefit from TVM surgery.
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