Evidence map›Paper›PMID 31402257›Full record

ArticleiScience2019

Bright Green Biofluorescence in Sharks Derives from Bromo-Kynurenine Metabolism.

Hyun Bong Park, Yick Chong Lam, Jean P Gaffney, James C Weaver, Sara Rose Krivoshik, Randy Hamchand, Vincent Pieribone, David F Gruber, Jason M Crawford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hyun Bong ParkDepartment of Chemistry, Yale University, New Haven, CT 06520, USA; Chemical Biology Institute, Yale University, West Haven, CT 06516, USA.
Yick Chong LamDepartment of Chemistry, Yale University, New Haven, CT 06520, USA; Chemical Biology Institute, Yale University, West Haven, CT 06516, USA.
Jean P GaffneyDepartment of Natural Sciences, City University of New York Baruch College, New York, NY 10010, USA; The Graduate Center Program in Biology, City University of New York Baruch College, New York, NY 10016, USA.
James C WeaverWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
Sara Rose KrivoshikDepartment of Natural Sciences, City University of New York Baruch College, New York, NY 10010, USA; The Graduate Center Program in Biology, City University of New York Baruch College, New York, NY 10016, USA.
Randy HamchandDepartment of Chemistry, Yale University, New Haven, CT 06520, USA; Chemical Biology Institute, Yale University, West Haven, CT 06516, USA.
Vincent PieriboneThe John B. Pierce Laboratory, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06519, USA.
David F GruberDepartment of Natural Sciences, City University of New York Baruch College, New York, NY 10010, USA; The Graduate Center Program in Biology, City University of New York Baruch College, New York, NY 10016, USA. Electronic address: david.gruber@baruch.cuny.edu.
Jason M CrawfordDepartment of Chemistry, Yale University, New Haven, CT 06520, USA; Chemical Biology Institute, Yale University, West Haven, CT 06516, USA; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USA. Electronic address: jason.crawford@yale.edu.

Funding

Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
NIGMS NIH HHS T32 GM067543
6 · The paper itself

Abstract

Although in recent years there has been an increased awareness of the widespread nature of biofluorescence in the marine environment, the diversity of the molecules responsible for this luminescent phenotype has been mostly limited to green fluorescent proteins (GFPs), GFP-like proteins, and fluorescent fatty acid-binding proteins (FABPs). In the present study, we describe a previously undescribed group of brominated tryptophan-kynurenine small molecule metabolites responsible for the green biofluorescence in two species of sharks and provide their structural, antimicrobial, and spectral characterization. Multi-scale fluorescence microscopy studies guided the discovery of metabolites that were differentially produced in fluorescent versus non-fluorescent skin, as well as the species-specific structural details of their unusual light-guiding denticles. Overall, this study provides the detailed description of a family of small molecules responsible for marine biofluorescence and opens new questions related to their roles in central nervous system signaling, resilience to microbial infections, and photoprotection.

Indexed as

ChemistryNatural Product ChemistryNatural Product Discovery

Identifiers

PMID31402257
PMCPMC6831821

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.