ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2020
Dysregulated insulin in pancreatic insufficient cystic fibrosis with post-prandial hypoglycemia.
Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05700604 (The Effect of Pancreatic Insufficiency on Hypoglycemia and Glucagon Response in Children With Cystic Fibrosis), which is not on this map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Pancreatic Insufficiency on Hypoglycemia and Glucagon Response in Children With Cystic Fibrosis
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Isolated Hypoglycemia in Children with Cystic Fibrosis: Role of Pancreatic Insufficiency and Glucagon ResponseJournal of clinical research in pediatric endocrinology · 2026Article
- The Impact of Cystic Fibrosis-Related Diabetes on Barriers to Self-Management.Pediatric pulmonology · 2026Article
- The Effect of Omnipod 5 Automated Insulin Delivery on Glycemic Control in Adolescents and Adults with Cystic Fibrosis-Related Diabetes.Diabetes technology & therapeutics · 2025Article
- Efficacy of advanced hybrid closed loop systems in cystic fibrosis related diabetes: a pilot study.Frontiers in endocrinology · 2024Article
- Characterization of impaired beta and alpha cell function in response to an oral glucose challenge in cystic fibrosis: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Endocrine Complications of Cystic Fibrosis.Clinics in chest medicine · 2022Review
- Bone metabolism and incretin hormones following glucose ingestion in young adults with pancreatic insufficient cystic fibrosis.Journal of clinical & translational endocrinology · 2022Article
- Practical aspects of diabetes technology use: Continuous glucose monitors, insulin pumps, and automated insulin delivery systems.Journal of clinical & translational endocrinology · 2022Article
- Spontaneous and iatrogenic hypoglycemia in cystic fibrosis.Journal of clinical & translational endocrinology · 2021Article
- Overview of Atypical Diabetes.Endocrinology and metabolism clinics of North America · 2020Review
- Hypoglycemia and Islet Dysfunction Following Oral Glucose Tolerance Testing in Pancreatic-Insufficient Cystic Fibrosis.The Journal of clinical endocrinology and metabolism · 2020Observational
- Impaired counterregulatory responses to hypoglycaemia following oral glucose in adults with cystic fibrosis.Diabetologia · 2020Article
- Rapid-Acting Insulin Used to Treat a Case of Early Cystic Fibrosis-Related Diabetes Complicated by Post Prandial Hypoglycemia.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPost-prandial and oral glucose tolerance test-related hypoglycemia is common in cystic fibrosis (CF); however, the underlying mechanisms are unclear.
methodsTo understand the relationship of hypoglycemia with meal-related glucose excursion and insulin secretion, we analyzed plasma glucose, insulin, C-peptide, glucagon and incretins obtained during standardized mixed-meal tolerance tests (MMTT) in non-diabetic adolescents and young adults with pancreatic insufficient CF (PI-CF).
resultsHypoglycemia, defined as glucose <70 mg/dL, occurred in 9/34 subjects at 150 (range:120-210) minutes following initial meal ingestion. Hypoglycemia[+] and hypoglycemia[-] groups did not differ in gender, age, lung function, HbA1c, or BMI. While 11/14 hypoglycemia[-] individuals displayed normal glucose tolerance (NGT), only 2/9 hypoglycemia[+] had NGT. Peak glucose was higher in hypoglycemia[+] vs hypoglycemia[-]. Compared to hypoglycemia[-] NGT, hypoglycemia[+] exhibited lower early-phase insulin secretion (ISR-AUC
conclusionHypoglycemia is common in PI-CF following MMTT and is associated with early glucose dysregulation (higher peak glucose), more impaired early-phase insulin secretion (lower ISR-AUC
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