ArticleNeuron2019
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 100 citations in OpenAlex.
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- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- Neural barcoding representing cortical spatiotemporal dynamics based on continuous-time Markov chains.Cell reports methods · 2026Article
- Muscle spindles provide flexible sensory feedback for movement sequences.Cell reports · 2025Article
- Mapping neural subspace dynamics onto the structure of the mouse descending motor system.bioRxiv : the preprint server for biology · 2025Article
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- Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels.bioRxiv : the preprint server for biology · 2025Article
- Separating cognitive and motor processes in the behaving mouse.Nature neuroscience · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
- A collicular map for touch-guided tongue control.Nature · 2025Article
- Hand-Jaw Coordination as Mice Handle Food Is Organized around Intrinsic Structure-Function Relationships.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024Review
- Goal-directed learning is multidimensional and accompanied by diverse and widespread changes in neocortical signaling.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- A prefrontal motor circuit initiates persistent movement.Nature communications · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural circuits underlying goal-directed sensorimotor transformations in the mammalian brain are incompletely understood. Here, we compared the role of primary tongue-jaw motor cortex (tjM1) and primary whisker sensory cortex (wS1) in head-restrained mice trained to lick a reward spout in response to whisker deflection. Two-photon microscopy combined with microprisms allowed imaging of neuronal network activity across cortical layers in transgenic mice expressing a genetically encoded calcium indicator. Early-phase activity in wS1 encoded the whisker sensory stimulus and was necessary for detection of whisker stimuli. Activity in tjM1 encoded licking direction during task execution and was necessary for contralateral licking. Pre-stimulus activity in tjM1, but not wS1, was predictive of lick direction and contributed causally to small preparatory jaw movements. Our data reveal a shift in coding scheme from wS1 to tjM1, consistent with the hypothesis that these areas represent cortical start and end points for this goal-directed sensorimotor transformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.