Evidence map›Paper›PMID 31402097›Full record

ArticleMolecular cell2019

Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P

Taki Nishimura, Michael Gecht, Roberto Covino, Gerhard Hummer, Michal A Surma, Christian Klose, Hiroyuki Arai, Nozomu Kono, Christopher J Stefan

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Regulation of yeast polarized exocytosis by phosphoinositide lipids.Cellular and molecular life sciences : CMLS · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Roles of Cholesterol and PtdIns(4,5)PAdvances in experimental medicine and biology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Taki NishimuraMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: taki.nishimura@crick.ac.uk.
Michael GechtDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Roberto CovinoDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Gerhard HummerDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany; Institute for Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Michal A SurmaLipotype GmbH, Tatzberg 47, 01307 Dresden, Germany.
Christian KloseLipotype GmbH, Tatzberg 47, 01307 Dresden, Germany.
Hiroyuki AraiDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; AMED-CREST, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyodaku, Tokyo 100-0004, Japan.
Nozomu KonoDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; PRIME, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyodaku, Tokyo 100-0004, Japan.
Christopher J StefanMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: c.stefan@ucl.ac.uk.
Genotype (Germany) · DEMax Planck Institute of Biophysics · DEUniversity College London · GBGoethe University Frankfurt · DEJapan Agency for Medical Research and Development · JPThe University of Tokyo · JP

Funding

Medical Research Council MC_UU_00012/6
6 · The paper itself

Abstract

The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are critical for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P

Indexed as

Carrier ProteinsPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeSaccharomyces cerevisiae Proteins1-phosphatidylinositol-4-phosphate 5-kinaseCarrier ProteinsPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiae ProteinsSWH1 protein, S cerevisiaeendoplasmic reticulumoxysterol-binding protein homology proteinphosphatidylinositol 4-phosphate 5-kinasephosphatidylserineplasma membranesterolunsaturated phospholipid

Identifiers

PMID31402097
PMCPMC6739424
OpenAlexW2913811044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.