ArticleSchizophrenia research2019
Impaired relational memory in the early stage of psychosis.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.Nature. Mental health · 2025Article
- Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.Brain sciences · 2024Article
- Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.Biological psychiatry global open science · 2023Article
- Habituation, Adaptation and Prediction Processes in Neurodevelopmental Disorders: A Comprehensive Review.Brain sciences · 2023Review
- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers.Current topics in behavioral neurosciences · 2023Article
- Memory-Based Prediction Deficits and Dorsolateral Prefrontal Dysfunction in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Article
- CCR5 closes the temporal window for memory linking.Nature · 2022Article
- Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.Schizophrenia research · 2022Article
- Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.Schizophrenia bulletin · 2021Article
- Relational memory in the early stage of psychotic bipolar disorder.Psychiatry research · 2020Article
- Retrieval practice facilitation of family psychoeducation in people with early psychosis.Schizophrenia research · 2020Article
- Habituation during encoding: A new approach to the evaluation of memory deficits in schizophrenia.Schizophrenia research · 2020Article
- Disordered directional brain network interactions during learning dynamics in schizophrenia revealed by multivariate autoregressive models.Human brain mapping · 2020Article
- Visual exploration differences during relational memory encoding in early psychosis.Psychiatry research · 2020Article
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Authors and funding
6 authors.
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Abstract
backgroundHumans constantly take in vast amounts of information, which must be filtered, flexibly manipulated, and integrated into cohesive relational memories in order to choose relevant behaviors. Relational memory is impaired in chronic schizophrenia, which has been linked to hippocampal dysfunction. It is unclear whether relational memory is impaired in the early stage of psychosis.
methodsWe studied eye movements during a face-scene pairs task as an indirect measure of relational memory in 89 patients in the early stage of psychosis and 84 healthy control participants. During testing, scenes were overlaid with three equally-familiar faces and participants were asked to recall the matching (i.e. previously-paired) face. During Match trials, one face had been previously paired with the scene. During Non-Match trials, no faces matched the scene. Forced-choice explicit recognition was recorded as a direct measure of relational memory.
resultsHealthy control subjects rapidly (within 250-500 ms) showed preferential viewing of the matching face during Match trials. In contrast, preferential viewing was delayed in patients in the early stage of psychosis. Explicit recognition of the matching face was also impaired in the patient group.
conclusionsThis study provides novel evidence for a relational memory deficit in the early stage of psychosis. Patients showed deficits in both explicit recognition as well as abnormal eye-movement patterns during memory recall. Eye movements provide a promising avenue for the study of relational memory in psychosis, as they allow for the assessment of rapid, nonverbal memory processes.
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