Evidence map›Paper›PMID 31402061›Full record

ArticleCell calcium2019

cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai.

Aldebaran M Hofer

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Aldebaran M HoferVA Boston Healthcare System and the Dept. of Surgery, Brigham & Women's Hospital and Harvard Medical School, 1400 VFW PKW, West Roxbury, MA 02132, USA. Electronic address: ahofer@rics.bwh.harvard.edu.
Harvard University · US

Funding

Georgetown-Howard Universities Center for Clinical and Translational Science (GHUKL2TR000102 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2014
$1.7M
Probing the cAMP signaling microdomain of the primary ciliumR21DE025921 · NIDCR · HARVARD MEDICAL SCHOOL · PI HOFER, ALDEBARAN M · 2016 to 2017
$354k
The ciliopathy-tauopathy connection in neurodegenerative disordersI21BX004093 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HOFER, ALDEBARAN M · 2018 to 2019
–
ShEEP Request for Leica SP8 Confocal Microscope with Light SheetIS1BX004786 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HOFER, ALDEBARAN M · 2019 to 2019
–
BLRD VA I21 BX004093BLRD VA IS1 BX004786NCATS NIH HHS KL2 TR000102NIDCR NIH HHS R21 DE025921
6 · The paper itself

Abstract

Calcium and cyclic AMP form the cornerstones of two ancient signaling systems represented in nearly every kingdom of life. Not surprisingly, these old and ubiquitous messenger molecules have co-evolved multiple means to regulate one another. Zhang et al. describe a new twist on this theme related to the intimate union between the calcium-activated adenylyl cyclase, AC8, and the store-operated Ca

Indexed as

Adenylyl CyclasesCalciumCalcium ChannelsCalcium SignalingMouthAdenylyl CyclasesCalciumCalcium ChannelsAdenylyl cyclaseCalcium channelsCyclic AMPElectrophysiologyPatch clamp

Identifiers

PMID31402061
PMCPMC7427263
OpenAlexW2964899167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.