ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Cross-species pathogen spillover across ecosystem boundaries: mechanisms and theory.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Pooled it
- Species-specific barriers restrict virus spillover potential across the Caenorhabditis genus.PLoS biology · 2026Article
- Mechanics of pandemics.EClinicalMedicine · 2026Review
- Targeting Zoonotic Spillover Drivers for Global Pandemic Prevention: A Narrative Review.Microorganisms · 2026Review
- Blood-feeding Patterns of Amazonian Forest Edge Mosquitoes.Research square · 2026Article
- Contrasting geographic patterns of parasite and hantavirus diversity in the rodent Oligoryzomys longicaudatus (Rodentia, Cricetidae).PLoS neglected tropical diseases · 2026Article
- Article
- Article
- Morphological and molecular detection of Hepatozoon species in amphibians and reptiles from Mato Grosso, Midwest Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Article
- Association between bat-predator species richness and Nipah virus spillover risk in Bangladesh.One health (Amsterdam, Netherlands) · 2025Article
- Forest fragment size shapesOne health (Amsterdam, Netherlands) · 2025Article
- Design and Implementation of a One Health Framework for Evaluating the Transmission Potential of Pathogens of Public Health Interest for Surveillance Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Influences of parental intimacy and self-disclosure on dyadic coping among parents raising school-aged children diagnosed with autism spectrum disorder.Journal of family medicine and primary care · 2025Article
- Host-Pathogen-Vector Continuum in a Changing Landscape: Potential Transmission Pathways forEcology and evolution · 2025Article
- Forest edge landscape context affects mosquito community composition and risk of pathogen emergence.iScience · 2025Article
- Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis.The ISME journal · 2025Article
- Habitat sharing and interspecies interactions in caves used by bats in the Republic of Congo.PeerJ · 2025Article
- Helminth parasites of the invasive European brown hare (Lepus europaeus) in Brazil: the first report of Bunostomum trigonocephalum in a hare.Parasitology research · 2024Article
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Detection of Leptospira kirschneri in a short-beaked common dolphin (Delphinus delphis delphis) stranded off the coast of southern California, USA.BMC veterinary research · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogen spillover between different host species is the trigger for many infectious disease outbreaks and emergence events, and ecosystem boundary areas have been suggested as spatial hotspots of spillover. This hypothesis is largely based on suspected higher rates of zoonotic disease spillover and emergence in fragmented landscapes and other areas where humans live in close vicinity to wildlife. For example, Ebola virus outbreaks have been linked to contacts between humans and infected wildlife at the rural-forest border, and spillover of yellow fever via mosquito vectors happens at the interface between forest and human settlements. Because spillover involves complex interactions between multiple species and is difficult to observe directly, empirical studies are scarce, particularly those that quantify underlying mechanisms. In this review, we identify and explore potential ecological mechanisms affecting spillover of pathogens (and parasites in general) at ecosystem boundaries. We borrow the concept of 'permeability' from animal movement ecology as a measure of the likelihood that hosts and parasites are present in an ecosystem boundary region. We then discuss how different mechanisms operating at the levels of organisms and ecosystems might affect permeability and spillover. This review is a step towards developing a general theory of cross-species parasite spillover across ecosystem boundaries with the eventual aim of improving predictions of spillover risk in heterogeneous landscapes. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.