ArticleKorean journal of pediatrics2019
Association between Body Mass Index and Hepatitis B antibody seropositivity in children.
Article in Korean journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Obesity drives dysregulation in DC responses to viral infection.Discovery immunology · 2025Article
- Early onset and increasing disparities in neurodevelopmental delays from birth to age 6 in children from low socioeconomic backgrounds.Journal of neurodevelopmental disorders · 2024Article
- Epidemiology of Chronic Hepatitis B Infection in the Cohort of College Students with Vaccination in Taiwan.Vaccines · 2023Article
- Body Mass Index and Antibody Persistence after Measles, Mumps, Rubella and Hepatitis B Vaccinations.Vaccines · 2022Article
- Association of Antibiotic Use during the First 6 Months of Life with Body Mass of Children.Antibiotics (Basel, Switzerland) · 2022Article
- Blood Lead Exposure and Association With Hepatitis B Core Antibody in the United States: NHANES 2011-2018.Frontiers in public health · 2022Article
- Is High Milk Intake Good for Children's Health? A National Population-Based Observational Cohort Study.Nutrients · 2021Observational
- Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008).Clinical and experimental pediatrics · 2021Article
- Breastmilk Feeding during the First 4 to 6 Months of Age and Childhood Disease Burden until 10 Years of Age.Nutrients · 2021Article
- Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children.Mediators of inflammation · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity. PURPOSE: To investigate whether body mass index (BMI) affects anti-HBs levels in healthy children following 3 serial dose vaccinations in infancy.
methodsWe recruited 1,200 healthy volunteers aged 3, 5, 7, or 10 years from 4-day care centers and 4 elementary schools. All subjects completed a questionnaire including body weight, height, and vaccine type received. Levels of serum hepatitis B surface antigen (HBsAg) and anti-HBs in all subjects were analyzed using electrochemiluminescence immunoassay. The standardized scores (z score) for each sex and age were obtained using the lambda-mu-sigma method in the 2017 Korean National Growth Charts for children and adolescents.
resultsOur subjects (n=1,200) comprised 750 males (62.5%) and 450 females (37.5%). The overall anti-HBs seropositivity rate was 57.9% (695 of 1,200). We identified significant differences in mean BMI values between seronegative and seropositive groups (17.45 vs. 16.62, respectively; P<0.001). The anti-HBs titer was significantly decreased as the BMI z score increased adjusting for age and sex (B=-15.725; standard error=5.494; P=0.004). The probability of anti-HBs seropositivity based on BMI z score was decreased to an OR of 0.820 after the control for confounding variables (95% confidence interval, 0.728-0.923; P=0.001).
conclusionThere was a significant association between anti-HBs titer and BMI z score after adjustment for age and sex. Our results indicate that BMI is a potential factor affecting anti-HBs titer in healthy children.
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