ArticleCell stress & chaperones2019
Transcriptional and post-translational activation of AMPKα by oxidative, heat, and cold stresses in the red flour beetle, Tribolium castaneum.
Article in Cell stress & chaperones, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Lipid Properties and Metabolism in Response to Cold.Advances in experimental medicine and biology · 2026Review
- Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases.PLoS genetics · 2023Article
- The pleiotropic AMPK-CncC signaling pathway regulates the trade-off between detoxification and reproduction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modulation of corticosterone and changes of signal molecules in the HPA axis after cold water swimming stress.Animal cells and systems · 2021Article
- Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum.BMC genomics · 2020Article
- Multi-lineage differentiation and clinical application of stem cells from exfoliated deciduous teeth.Human cell · 2020Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
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Abstract
The AMP-activated protein kinase (AMPK) has important roles in the regulation of energy metabolism, and AMPK activity and its regulation have been the focus of relevant investigations. However, functional characterization of AMPK is still limited in insects. In this study, the full-length cDNA coding AMPKα (TcAMPKα) was isolated from the red flour beetle, Tribolium castaneum. The TcAMPKα gene contains an ORF of 1581 bp encoding a protein of 526 amino acid residues, which shared conserved domain structure with Drosophila melanogaster and mammalian orthologs. Exposure of female adults to oxidative, heat, and cold stresses caused an increase in TcAMPKα mRNA expression levels and phosphorylation of Thr-173 in the activation loop. The RNAi-mediated knockdown of TcAMPKα resulted in the increased sensitivity of T. castaneum to oxidative, heat, and cold stresses. These results suggest that stress signals regulate TcAMPKα activity, and TcAMPKα plays an important role in enabling protective mechanisms and processes that confer resistance to environmental stress.
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