Evidence map›Paper›PMID 31401708›Full record

ArticleFish physiology and biochemistry2019

GSK3β inhibition suppresses the hepatic lipid accumulation in Schizothorax prenanti.

Yan Wang, Xiaochen Zhan, Wei Luo, Liulan Zhao, Song Yang, Defang Chen, Zhiqiong Li, Linjie Wang

Abstract read
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In one paragraph

Article in Fish physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Oxidative damages and antioxidant defences after feeding a single meal in rainbow trout.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan WangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Xiaochen Zhan
Wei LuoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Liulan ZhaoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Song YangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Defang ChenCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Zhiqiong LiCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Linjie WangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China. wanglinjie@sicau.edu.cn.
Sichuan Agricultural University · CN

Funding

National Natural Science Foundation of China 31602148
6 · The paper itself

Abstract

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine kinase involved in the regulation of embryonic development, glycogen metabolism, protein synthesis, mitosis, and apoptosis. To understand the role of GSK3β in hepatic lipid accumulation of Schizothorax prenanti, we used lithium chloride (LiCl), a GSK3β inhibitor, to inhibit the expression and activity of GSK3β. LiCl increased levels of phosphorylation of GSK3β (Ser9) and decreased the protein level of GSK3β. Plasma TG, TC, and LDL-C levels were greatly decreased after LiCl treatment. Additionally, GSK3β inhibition significantly reduced the levels of hepatic triglyceride (TG) and decreased the expression of lipogenesis-related genes in liver. Interestingly, LiCl decreased levels of phosphorylation of STAT3 (Tyr705), and then inhibited the activity of STAT3. These results indicate that in vivo LiCl treatment, which inhibited GSK3β activity, effectively decreased hepatic lipid accumulation through STAT3 in Schizothorax prenanti.

Indexed as

Lipid MetabolismAnimalsCyprinidaeGlycogen Synthase Kinase 3 betaLipidsLipogenesisLithium ChlorideLiverPhosphorylationRandom AllocationSTAT3 Transcription FactorGlycogen Synthase Kinase 3 betaLipidsLithium ChlorideSTAT3 Transcription FactorGSK3βHepatic lipidLiClSchizothorax prenantiSTAT3

Identifiers

PMID31401708
OpenAlexW2969200179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.