ArticleJournal of experimental botany2019
Histone acetyltransferase GCN5-mediated regulation of long non-coding RNA At4 contributes to phosphate starvation response in Arabidopsis.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Long-Distance Trafficking of Mineral Elements From Soil-to-Seed Under Climate Change Impacts Crop Nutritional Quality.Plant, cell & environment · 2026Review
- Reciprocal control of metabolic and chromatin regulators improves rice tolerance to heat.Nature communications · 2025Article
- Epigenetic Regulation of Salt Stress Responses in Rice: Mechanisms and Prospects for Enhancing Tolerance.Epigenomes · 2025Review
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- From genes to traits: maximizing phosphorus utilization efficiency in crop plants.Frontiers in plant science · 2025Review
- The transcription factor CAMTA2 interacts with the histone acetyltransferase GCN5 and regulates grain weight in wheat.The Plant cell · 2024Article
- Underground communication: Long non-coding RNA signaling in the plant rhizosphere.Plant communications · 2024Review
- Multi-locus genome-wide association study for phosphorus use efficiency in a tropical maize germplasm.Frontiers in plant science · 2024Article
- Roles of long non-coding RNAs in plant immunity.PLoS pathogens · 2023Review
- Epigenetic modifications: Allusive clues of lncRNA functions in plants.Computational and structural biotechnology journal · 2023Review
- Genome-wide investigation of histone acetyltransferase gene family and its responses to biotic and abiotic stress in foxtail millet (Setaria italica [L.] P. Beauv).BMC plant biology · 2022Article
- Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma.Applied microbiology and biotechnology · 2022Article
- Minireview: Chromatin-based regulation of iron homeostasis in plants.Frontiers in plant science · 2022Review
- Epigenetic regulation of salinity stress responses in cereals.Molecular biology reports · 2022Review
- Global proteome analyses of phosphorylation and succinylation of barley root proteins in response to phosphate starvation and recovery.Frontiers in plant science · 2022Article
- Histone variants and modifications during abiotic stress response.Frontiers in plant science · 2022Review
- Genome-wide analysis of long non-coding RNAs (lncRNAs) in two contrasting soybean genotypes subjected to phosphate starvation.BMC genomics · 2021Article
- Histone acetylation dynamics regulating plant development and stress responses.Cellular and molecular life sciences : CMLS · 2021Review
- Review
- The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants.Plants (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphate availability is becoming a limiting environmental factor that inhibits plant growth and development. Here, we demonstrated that mutation of the histone acetyltransferase GCN5 impaired phosphate starvation responses (PSRs) in Arabidopsis. Transcriptome analysis revealed that 888 GCN5-regulated candidate genes were potentially involved in responding to phosphate starvation. ChIP assay indicated that four genes, including a long non-coding RNA (lncRNA) At4, are direct targets of GCN5 in PSR regulation. In addition, GCN5-mediated H3K9/14 acetylation of At4 determined dynamic At4 expression. Consistent with the function of At4 in phosphate distribution, mutation of GCN5 impaired phosphate accumulation between shoots and roots under phosphate deficiency condition, whereas constitutive expression of At4 in gcn5 mutants partially restored phosphate relocation. Further evidence proved that GCN5 regulation of At4 influenced the miRNA miR399 and its target PHO2 mRNA level. Taken together, we propose that GCN5-mediated histone acetylation plays a crucial role in PSR regulation via the At4-miR399-PHO2 pathway and provides a new epigenetic mechanism for the regulation of lncRNA in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.