ArticleBMJ open2019
Association between normal triglyceride and insulin resistance in US adults without other risk factors: a cross-sectional study from the US National Health and Nutrition Examination Survey, 2007-2014.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 10 citations in OpenAlex.
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- Dose-response relationships of normal blood lipid levels in metabolic and endocrine diseases: mechanistic similarities, differences, and functional insights.Frontiers in endocrinology · 2026Review
- Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort study from the China health and retirement longitudinal study.Diabetology & metabolic syndrome · 2025Article
- Triglyceride-glycated hemoglobin index as a superior predictor of type 2 diabetes risk in a large-scale retrospective cohort study.Scientific reports · 2025Article
- Non-linear relationship between lipid accumulation products and risk of diabetes in Japanese adults.Scientific reports · 2024Article
- Nonlinear relationship between triglyceride-glucose index and the risk of prediabetes and diabetes: a secondary retrospective cohort study.Frontiers in endocrinology · 2024Article
- Post-treatment serum triglyceride: An effective biomarker for body fat mass and overall survival in esophageal squamous cell cancer patients treated with chemoradiotherapy.Frontiers in nutrition · 2022Article
- Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes.BMC endocrine disorders · 2021Article
- Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
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15 authors at 1 institution in 1 country.
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Abstract
objectiveTraditionally, the absence of insulin resistance risk factors (IRRFs) was considered a low risk for insulin resistance (IR). However, IR also existed in certain individuals without IRRFs; thus this study aims to explore predictors of IR targeted at the population without IRRFs.
designCross-sectional survey.
settingNational Health and Nutrition Examination Survey.
participantsParticipants without regular IRRFs (IRRF-Free, n=2478) and a subgroup without optimal IRRFs (IRRF-Optimal, n=1414) were involved in this study. PRIMARY AND SECONDARY OUTCOME MEASURE: IRRFs and the optimal cut-off value of triglyceride (TG) to predict IR.
resultsOverall, the prevalence of IR was 6.9% and 5.7% in the IRRF-Free group and the IRRF-Optimal group, respectively. TG and waist circumference were independently associated with the prevalence of IR in both the groups (OR=1.010 to 10.20; p<0.05 for all), where TG was positively associated with IR. The area under the receiver operating characteristic curve of TG was 0.7016 (95% CI: 0.7013 to 0.7018) and 0.7219 (95% CI: 0.7215 to 0.7222), and the optimal cut-off value of TG to predict IR was 79.5 mg/dL and 81.5 mg/dL in the IRRF-Free group and the IRRF-Optimal group, respectively.
conclusionThere is an association between TG and IR even in the normal range of TG concentration. Therefore, normal TG could be used as an important indicator to predict the prevalence of IR in the absence of IRRFs.
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