ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02224469 (Utrecht Neural Prosthesis), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utrecht Neural Prosthesis (UNP): A Pilot Study on Controllability of Brain Signals and Application in locked-in Patients
Who cites it
47 citing papers in PubMed, 94 citations in OpenAlex.
- Optimal Size of Electrocorticography Grids for Classification of Hand Movements.Neuroinformatics · 2026Article
- Long-term unsupervised recalibration of cursor-based intracortical brain-computer interfaces using a hidden Markov model.Nature biomedical engineering · 2026Article
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Stable speech BCI performance during slow progression of ALS: A longitudinal ECoG study.Research square · 2026Article
- Movement-responsive deep brain stimulation for Parkinson's disease using a remotely optimized neural decoder.Nature biomedical engineering · 2026Article
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- sEEG-based brain-computer interfacing in a large adult and pediatric cohort.Journal of neural engineering · 2025Article
- Longitudinal study of gesture decoding in a clinical trial participant with ALS.medRxiv : the preprint server for health sciences · 2025Article
- Signal properties and stability of a chronically implanted endovascular brain computer interface.medRxiv : the preprint server for health sciences · 2025Article
- Don't put words in my mouth: speech perception can falsely activate a brain-computer interface.Journal of neuroengineering and rehabilitation · 2025Article
- 5-year follow-up of a fully implanted brain-computer interface in a spinal cord injury patient.Journal of neural engineering · 2025Article
- Invasive Brain-Computer Interface for Communication: A Scoping Review.Brain sciences · 2025Review
- Article
- Effects of Packet Loss on Neural Decoding Effectiveness in Wireless Transmission.Brain sciences · 2025Article
- Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review.Fundamental research · 2025Review
- Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Review
- A click-based electrocorticographic brain-computer interface enables long-term high-performance switch scan spelling.Communications medicine · 2024Article
- Chrono-EEG dynamics influencing hand gesture decoding: a 10-hour study.Scientific reports · 2024Article
- Longevity of a Brain-Computer Interface for Amyotrophic Lateral Sclerosis.The New England journal of medicine · 2024Article
- A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages.Nature biomedical engineering · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWe investigated the long-term functional stability and home use of a fully implanted electrocorticography (ECoG)-based brain-computer interface (BCI) for communication by an individual with late-stage Amyotrophic Lateral Sclerosis (ALS).
methodsData recorded from the cortical surface of the motor and prefrontal cortex with an implanted brain-computer interface device was evaluated for 36 months after implantation of the system in an individual with late-stage ALS. In addition, electrode impedance and BCI control accuracy were assessed. Key measures included frequency of use of the system for communication, user and system performance, and electrical signal characteristics.
resultsUser performance was high consistently over the three years. Power in the high frequency band, used for the control signal, declined slowly in the motor cortex, but control over the signal remained unaffected by time. Impedance increased until month 5, and then remained constant. Frequency of home use increased steadily, indicating adoption of the system by the user.
conclusionsThe implanted brain-computer interface proves to be robust in an individual with late-stage ALS, given stable performance and control signal for over 36 months. SIGNIFICANCE: These findings are relevant for the future of implantable brain-computer interfaces along with other brain-sensing technologies, such as responsive neurostimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.