Evidence map›Paper›PMID 31400914›Full record

ArticleBiophysical journal2019

Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.

Patrick Ernst, Ningning Xu, Jing Qu, Herbert Chen, Matthew S Goldberg, Victor Darley-Usmar, Jianyi J Zhang, Brian O'Rourke, Xiaoguang Liu, Lufang Zhou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Optogenetic Studies of Mitochondria.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Patrick ErnstDepartments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama; Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ningning XuDepartments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama.
Jing QuMedicine, University of Alabama at Birmingham, Birmingham, Alabama.
Herbert ChenSurgery, University of Alabama at Birmingham, Birmingham, Alabama.
Matthew S GoldbergNeurology, University of Alabama at Birmingham, Birmingham, Alabama.
Victor Darley-UsmarPathology, University of Alabama at Birmingham, Birmingham, Alabama.
Jianyi J ZhangDepartments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama.
Brian O'RourkeDivision of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.
Xiaoguang LiuDepartments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama.
Lufang ZhouDepartments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama; Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: lfzhou@uab.edu.
University of Alabama at Birmingham · USJohns Hopkins University · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Targeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1M
Molecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0M
Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing HeartsR01HL121206 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, LUFANG · 2015 to 2019
$1.8M
A Novel Optogenetic Tool for Precise Mitochondrial ControlR21HL127599 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, LUFANG · 2016 to 2017
$405k
NHLBI NIH HHS R01 HL121206NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL137259NHLBI NIH HHS R21 HL127599NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Mitochondrial dysfunction has been implicated in many pathological conditions and diseases. The normal functioning of mitochondria relies on maintaining the inner mitochondrial membrane potential (also known as ΔΨm) that is essential for ATP synthesis, Ca

Indexed as

ApoptosisMembrane Potential, MitochondrialCells, CulturedChannelrhodopsinsHeLa CellsHumansMitochondriaOptogeneticsUbiquitin-Protein LigasesChannelrhodopsinsparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID31400914
PMCPMC6712847
OpenAlexW2966399348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.