Evidence map›Paper›PMID 31400397›Full record

ArticleMolecular and cellular endocrinology2019

Effect of SULT2B1 genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by SULT2B1b allozymes.

Fatemah A Alherz, Amal A El Daibani, Maryam S Abunnaja, Ahsan F Bairam, Mohammed I Rasool, Yoichi Sakakibara, Masahito Suiko, Katsuhisa Kurogi, Ming-Cheh Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Human sulfotransferaseFrontiers in genetics · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Fatemah A AlherzDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: Fatemah.Alherz@rockets.utoledo.edu.
Amal A El DaibaniDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA. Electronic address: Amal.ElDaibani@rockets.utoledo.edu.
Maryam S AbunnajaDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA. Electronic address: Maryam.Abunnaja@rockets.utoledo.edu.
Ahsan F BairamDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA; Department of Pharmacology, College of Pharmacy, University of Kufa, Najaf, Iraq. Electronic address: Ahsan.Bairam@rockets.utoledo.edu.
Mohammed I RasoolDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA; Department of Pharmacology, College of Pharmacy, University of Karbala, Karbala, Iraq. Electronic address: Mohammed.Rasool@rockets.utoledo.edu.
Yoichi SakakibaraBiochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, 889-2192, Japan. Electronic address: ysakaki@cc.miyazaki-u.ac.jp.
Masahito SuikoBiochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, 889-2192, Japan. Electronic address: msuiko@cc.miyazaki-u.ac.jp.
Katsuhisa KurogiDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA; Biochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, 889-2192, Japan. Electronic address: katsu1982@cc.miyazaki-u.ac.jp.
Ming-Cheh LiuDepartment of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH, 43614, USA. Electronic address: ming.liu@utoledo.edu.
University of Miyazaki · JPUniversity of Toledo · USKing Saud University · SAUniversity of Kerbala · IQUniversity of Kufa · IQ

Funding

Ontogeny of the Phase II cytosolic sulfotransferases and adverse drug reactionsR03HD071146 · NICHD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI LIU, MING-CHEH · 2012 to 2013
$146k
NICHD NIH HHS R03 HD071146
6 · The paper itself

Abstract

Pregnenolone and dehydroepiandrosterone (DHEA) are hydroxysteroids that serve as biosynthetic precursors for steroid hormones in human body. SULT2B1b has been reported to be critically involved in the sulfation of pregnenolone and DHEA, particularly in the sex steroid-responsive tissues. The current study was designed to investigate the impact of the genetic polymorphisms of SULT2B1 on the sulfation of DHEA and pregnenolone by SULT2B1b allozymes. Ten SULT2B1b allozymes previously prepared were shown to exhibit differential sulfating activities toward DHEA and pregnenolone in comparison to the wild-type enzyme. Kinetic studies revealed further significant changes in their substrate-binding affinity and catalytic activity toward DHEA and pregnenolone. Taken together, these results indicated clearly a profound effect of SULT2B1 genetic polymorphisms on the sulfating activity of SULT2B1b allozymes toward DHEA and pregnenolone, which may have implications in inter-individual variations in the homeostasis of these two important steroid precursors.

Indexed as

Polymorphism, Single NucleotideDehydroepiandrosteroneHumansIsoenzymesPregnenoloneSulfotransferasesDehydroepiandrosteroneIsoenzymesPregnenoloneSulfotransferasesSULT2B1 protein, humanDHEAPregnenoloneSingle nucleotide polymorphismsSULTSULT2B1b

Identifiers

PMID31400397
PMCPMC6733586
OpenAlexW2966706880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.