Evidence map›Paper›PMID 31400350›Full record

ReviewAdvanced drug delivery reviews2019

Nanocarrier-based systems for targeted and site specific therapeutic delivery.

Joydeb Majumder, Oleh Taratula, Tamara Minko

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  10. Polymeric nanocarriers for subcellular targeting in photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Review
  11. Article
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  17. Metal oxide nanoparticles: emerging stars in biomedical application.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
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  19. Article
  20. Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joydeb MajumderDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.
Oleh TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, USA.
Tamara MinkoDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Environmental and Occupational Health Science Institute, Piscataway, NJ 08854, USA. Electronic address: minko@pharmacy.rutgers.edu.

Funding

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer CachexiaR37CA234006 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2019 to 2025
$3.2M
Bionanotechnology approach for treatment of lung cancerR01CA238871 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MINKO, TAMARA · 2019 to 2023
$2.9M
Tumor-targeted nanoparticle-based delivery system for imaging and treatment of cancerR01CA209818 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI MINKO, TAMARA · 2017 to 2021
$2.3M
Nanotechnology Approach for Inhalation Treatment of Pulmonary FibrosisR01HL118312 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI MINKO, TAMARA · 2014 to 2017
$1.9M
Combinatorial Nanotherapeutic Approach for Advanced Prostate Cancer TreatmentR15EB020351 · NIBIB · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2016 to 2016
$441k
NCI NIH HHS R01 CA209818NCI NIH HHS R01 CA238871NCI NIH HHS R37 CA234006NHLBI NIH HHS R01 HL118312NIBIB NIH HHS R15 EB020351
6 · The paper itself

Abstract

Systemic drug delivery methods such as oral or parenteral administration of free drugs possess relatively low treatment efficiency and marked adverse side effects. The use of nanoparticles for drug delivery in most cases substantially enhances drug efficacy, improves pharmacokinetics and drug release and limits their side effects. However, further enhancement in drug efficacy and significant limitation of adverse side effects can be achieved by specific targeting of nanocarrier-based delivery systems especially in combination with local administration. The present review describes major advantages and limitations of organic and inorganic nanocarriers or living cell-based drug and nucleic acid delivery systems. Among these, different nanoparticles, supramolecular gels, therapeutic cells as living drug carriers etc. have emerged as a new frontier in modern medicine.

Indexed as

Drug Delivery SystemsAnimalsHumansNanoparticlesNeoplasmsCell-based carriersDrugDrug targetingOrganic and inorganic nanoparticlessiRNA and nucleotide deliverySupramolecular gel

Identifiers

PMID31400350
PMCPMC6748653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.