Evidence map›Paper›PMID 31400305›Full record

ArticleBiochimica et biophysica acta. Biomembranes2020

Intrinsically disordered HAX-1 regulates Ca

Erik K Larsen, Daniel K Weber, Songlin Wang, Tata Gopinath, Daniel J Blackwell, Michael P Dalton, Seth L Robia, Jiali Gao, Gianluigi Veglia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Erik K LarsenDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel K WeberDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Songlin WangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Tata GopinathDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel J BlackwellDepartment of Physiology, Loyola University, Maywood, IL 60153, USA.
Michael P DaltonDepartment of Physiology, Loyola University, Maywood, IL 60153, USA.
Seth L RobiaDepartment of Physiology, Loyola University, Maywood, IL 60153, USA.
Jiali GaoDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; School of Chemical Biology and Technology, Beijing University Graduate School, Shenzhen 518055, China.
Gianluigi VegliaDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: vegli001@umn.edu.
University of Minnesota · USLoyola University Chicago · US

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
NMR Structural Analysis of Calcium Regulation in MuscleR01GM064742 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VEGLIA, GIANLUIGI · 2002 to 2019
$7.1M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL143816NIGMS NIH HHS R01 GM064742
6 · The paper itself

Abstract

Hematopoietic-substrate-1 associated protein X-1 (HAX-1) is a 279 amino acid protein expressed ubiquitously. In cardiac muscle, HAX-1 was found to modulate the sarcoendoplasmic reticulum calcium ATPase (SERCA) by shifting its apparent Ca

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCalciumCalcium-Binding ProteinsCytoplasmHumansIntrinsically Disordered ProteinsMagnetic Resonance SpectroscopyMembrane LipidsMyocardiumPhospholambanProtein Structure, SecondarySarcoplasmic Reticulum Calcium-Transporting ATPasesAdaptor Proteins, Signal TransducingCalciumCalcium-Binding ProteinsHAX1 protein, humanIntrinsically Disordered ProteinsMembrane LipidsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesHAX-1Intrinsically disordered proteinsNMR spectroscopyPhospholambanProtein-membrane interactions

Identifiers

PMID31400305
PMCPMC6899184
OpenAlexW2966179431

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.