Evidence map›Paper›PMID 31400092›Full record

ArticleESC heart failure2019

Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications.

Shih-Chieh Chien, Chi-In Lo, Chao-Feng Lin, Kuo-Tzu Sung, Jui-Peng Tsai, Wen-Hung Huang, Chun-Ho Yun, Ta-Chuan Hung, Jiun-Lu Lin, Chia-Yuan Liu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Shih-Chieh ChienDepartment of Critical Care Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Chi-In LoDepartment of Critical Care Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Chao-Feng LinDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Kuo-Tzu SungDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Jui-Peng TsaiDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Wen-Hung HuangDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Chun-Ho YunDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Ta-Chuan HungDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.ORCID 0000-0003-1845-242X
Jiun-Lu LinDivision of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Chia-Yuan LiuDivision of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Charles Jia-Yin HouDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
I-Hsien TsaiNutritional Medicine Center, MacKay Memorial Hospital, Taipei, Taiwan.
Cheng-Huang SuDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Hung-I YehDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Chung-Lieh HungDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Mackay Memorial Hospital · TW

Funding

Hsinchu MacKay Memorial Hospital E-101-11Mackay Memorial Hospital 10220Mackay Memorial Hospital 10248Mackay Memorial Hospital 10253Mackay Memorial Hospital 10271Mackay Memorial Hospital 10271, 10248, 10220, 10253, 10375, 10358, E-102003Mackay Memorial Hospital 10358Mackay Memorial Hospital 10375Mackay Memorial Hospital E-102003Ministry of Science and Technology, Taiwan 101-2314-B-195-020-MY1Ministry of Science and Technology, Taiwan 103-2314-B-195-001-MY3Ministry of Science and Technology, Taiwan MOST 103-2314-B-195-006-MY3Ministry of Science and Technology, Taiwan MOST 105-2632-B-715-001Ministry of Science and Technology, Taiwan MOST 106-2314-B-195-008-MY2Ministry of Science and Technology, Taiwan NSC-101-2314-B-195-020Ministry of Science and Technology, Taiwan NSC-101-2314-B-195-020, NSC103- 2314-B-010-005-MY3, 103-2314-B-195-001-MY3, 101-2314-B- 195-020-MY1, MOST 103-2314-B-195-006-MY3, MOST 105-2632-B-715-001, MOST 106-2314-B-195-008-MY2, NSC102- 2314-B-002-046-MY3Ministry of Science and Technology, Taiwan NSC102-2314-B-002-046-MY3Ministry of Science and Technology, Taiwan NSC103-2314-B-010-005-MY3National Taiwan University 105R7879National Taiwan University 1104R7879National Taiwan University NTU-CDP-103R7879National Taiwan University NTU-CDP-103R7879, 1104R7879 and 105R7879Taipei Medical University TMU103-AE1-B14Taiwan Foundation for Geriatric Emergency and Critical Care 2014Taiwan Foundation for Geriatric Emergency and Critical Care 2014, 2015Taiwan Foundation for Geriatric Emergency and Critical Care 2015
6 · The paper itself

Abstract

aimsThis study aimed to evaluate the prognostic significance of nutritional status in post-discharge Asians with heart failure with preserved ejection fraction (HFpEF). METHODS AND

resultsWe examined the prognostic implications of body mass index (BMI) and nutritional markers among consecutive patients hospitalized for HFpEF. Nutritional metrics were estimated by serum albumin (SA), prognostic nutritional index (PNI), Controlling Nutritional Status (CONUT) score, and geriatric nutritional risk index. Among 1120 patients (mean age: 77.2 ± 12.6 years, 39.4% men), mean SA levels, PNI, CONUT scores, and geriatric nutritional risk index were 3.3 ± 0.6 g/dL, 40.2 ± 8.7, 5.5 ± 2.1, and 95.9 ± 14.5, respectively. Lean body size, higher white blood cell counts and C-reactive protein levels, anaemia, and lack of angiotensin blocker use were independently associated with malnutrition (defined by SA < 3.5 g/dL). Higher SA levels [hazard ratio (HR): 0.67 (95% confidence interval, CI: 0.53-0.85)], higher PNI [HR: 0.97 (95% CI: 0.95-0.99)], and higher geriatric nutritional risk index [HR: 0.98 (95% CI: 0.97-0.99)] (all P < 0.05) were all associated with longer survival, with higher CONUT score [HR: 1.08 (95% CI: 1.02-1.13)] exhibited higher mortality in Cox regression models and with higher SA levels/PNI but not BMI further contributing to the reduced rate of re-hospitalization (both P < 0.05). Categorizing BMI (25 kg/m

conclusionsMalnutrition was frequently and strongly associated with systemic inflammation in Asian patients hospitalized for acute HFpEF. Our findings also indicate that nutrition may play a pivotal role in metabolic protection in this population.

Indexed as

Acute DiseaseAgedAged, 80 and overAnemiaAsian PeopleBiomarkersBody Mass IndexC-Reactive ProteinFemaleGeriatric AssessmentHeart FailureHospitalizationHumansLeukocyte CountMaleMalnutritionBiomarkersC-Reactive ProteinSerum AlbuminAlbuminBody mass indexHeart failure with preserved ejection fractionMortalityNutritional status

Identifiers

PMID31400092
PMCPMC6816066
OpenAlexW2967381667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.