Evidence map›Paper›PMID 31400034›Full record

ArticleMagnetic resonance in medicine2020

CEST MR-Fingerprinting: Practical considerations and insights for acquisition schedule design and improved reconstruction.

Or Perlman, Kai Herz, Moritz Zaiss, Ouri Cohen, Matthew S Rosen, Christian T Farrar

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. "MR Fingerprinting for Imaging Brain Hemodynamics and Oxygenation".Journal of magnetic resonance imaging : JMRI · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. iScience · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Or PerlmanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.ORCID 0000-0002-3566-569X
Kai HerzMagnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID 0000-0002-7286-1454
Moritz ZaissMagnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID 0000-0001-9780-3616
Ouri CohenMemorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-3632-8094
Matthew S RosenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.ORCID 0000-0002-7194-002X
Christian T FarrarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.ORCID 0000-0001-6623-8220
Harvard University · USMax Planck Institute for Biological Cybernetics · DEMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
A CEST-MRI Reporter Gene for Image Guided Oncolytic VirotherapyR01CA203873 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FARRAR, CHRISTIAN T · 2016 to 2020
$1.9M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA203873NCRR NIH HHS P41 RR014075NIH HHS P41-RR14075
6 · The paper itself

Abstract

purposeTo understand the influence of various acquisition parameters on the ability of CEST MR-Fingerprinting (MRF) to discriminate different chemical exchange parameters and to provide tools for optimal acquisition schedule design and parameter map reconstruction.

methodsNumerical simulations were conducted using a parallel computing implementation of the Bloch-McConnell equations, examining the effect of TR, TE, flip-angle, water

resultsSimulations for dot product matching demonstrated that the optimal flip-angle and saturation times are

conclusionsOptimization of the CEST-MRF acquisition schedule is critical for obtaining the best exchange parameter accuracy. The use of Euclidean distance-based matching of signal trajectories simultaneously improved the discrimination ability and reduced the scan time and maximal saturation power required.

Indexed as

Magnetic Resonance ImagingAlgorithmsArginineComputer SimulationHumansHydrogen-Ion ConcentrationImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedLinear ModelsPhantoms, ImagingProgramming LanguagesProtonsReproducibility of ResultsSoftwareArginineProtonschemical exchange ratechemical exchange saturation transfer (CEST)magnetic resonance fingerprinting (MRF)optimizationpHquantitative imaging

Identifiers

PMID31400034
PMCPMC7190069
OpenAlexW2939928648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.