ArticlePlant molecular biology2019
Proteomic characterization of MPK4 signaling network and putative substrates.
Article in Plant molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Mitogen-Activated Protein Kinase 4-Regulated Metabolic Networks.International journal of molecular sciences · 2022Article
- The Chorion Proteome ofInsects · 2021Article
- HopA1 Effector fromInternational journal of molecular sciences · 2021Article
- Proteomics of Homeobox7 Enhanced Salt Tolerance inInternational journal of molecular sciences · 2021Article
- Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans.Molecular plant pathology · 2021Article
- Proteomics data of SNF1-related protein kinase 2.4 interacting proteins revealed by immunoprecipitation-mass spectrometry.Data in brief · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
key messageCombining genetic engineering of MPK4 activity and quantitative proteomics, we established an in planta system that enables rapid study of MPK4 signaling networks and potential substrate proteins. Mitogen activated protein kinase 4 (MPK4) is a multifunctional kinase that regulates various signaling events in plant defense, growth, light response and cytokinesis. The question of how a single protein modulates many distinct processes has spurred extensive research into the physiological outcomes resulting from genetic perturbation of MPK4. However, the mechanism by which MPK4 functions is still poorly understood due to limited data on the MPK4 networks including substrate proteins and downstream pathways. Here we introduce an experimental system that combines genetic engineering of kinase activity and quantitative proteomics to rapidly study the signaling networks of MPK4. First, we transiently expressed a constitutively active (MPK4
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