Evidence map›Paper›PMID 31399838›Full record

ArticleCellular and molecular neurobiology2020

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice.

I S Zhukov, L G Kubarskaya, I Y Tissen, A A Kozlova, S G Dagayev, V A Kashuro, O L Vlasova, E L Sinitca, I V Karpova, R R Gainetdinov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

I S ZhukovInstitute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, Universitetskaya nab., 7-9, Saint Petersburg, Russia, 199034. ilya.zhukov@skolkovotech.ru.ORCID http://orcid.org/0000-0001-7945-5486
L G KubarskayaInstitute of Toxicology of Federal Medical-Biological Agency, Bekhtereva str. 1., Saint Petersburg, Russia, 192019.
I Y TissenInstitute of Experimental Medicine, Acad. Pavlov str. 12, Saint Petersburg, Russia, 197376.
A A KozlovaInstitute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, Universitetskaya nab., 7-9, Saint Petersburg, Russia, 199034.
S G DagayevInstitute of Toxicology of Federal Medical-Biological Agency, Bekhtereva str. 1., Saint Petersburg, Russia, 192019.
V A KashuroInstitute of Toxicology of Federal Medical-Biological Agency, Bekhtereva str. 1., Saint Petersburg, Russia, 192019.
O L VlasovaPeter the Great Saint Petersburg Polytechnic University, Polytechnicheskaya str. 29, Saint Petersburg, Russia, 195251.
E L SinitcaInstitute of Experimental Medicine, Acad. Pavlov str. 12, Saint Petersburg, Russia, 197376.
I V KarpovaInstitute of Experimental Medicine, Acad. Pavlov str. 12, Saint Petersburg, Russia, 197376.
R R GainetdinovInstitute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, Universitetskaya nab., 7-9, Saint Petersburg, Russia, 199034.
Federal Medical-Biological Agency · RUInstitute of Experimental Medicine · RUSt Petersburg University · RUPeter the Great St. Petersburg Polytechnic University · RUSkolkovo Institute of Science and Technology · RU

Funding

Russian Science Foundation grant N 19-75-30008
6 · The paper itself

Abstract

Since the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the peripheral organs is less investigated. Expression of TAAR1 was demonstrated in different peripheral tissues: pancreatic β-cells, stomach, intestines, white blood cells (WBC), and thyroid. However, the role of TAAR1 in regulation of hematological parameters has not been investigated yet. In this study, we performed analysis of anxiety-related behaviors, a complete blood count (CBC), erythrocyte fragility, as well as FT3/FT4 thyroid hormones levels in adult and middle-aged TAAR1 knockout mice. Complete blood count analysis was performed on a Siemens Advia 2120i hematology analyzer and included more than 35 measured and calculated parameters. Erythrocyte fragility test evaluated spherocytosis pathologies of red blood cells (RBC). No significant alterations in essentially all these parameters were found in mice without TAAR1. However, comparative aging analysis has revealed a decreased neutrophils level in the middle-aged TAAR1 knockout mouse group. Minimal alterations in these parameters observed in TAAR1 knockout mice suggest that future TAAR1-based therapies should exert little hematological effect and thus will likely have a good safety profile.

Indexed as

Age FactorsAnimalsAnxietyDose-Response Relationship, DrugMaleMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutReceptors, G-Protein-CoupledSodium ChlorideTrace Amine-Associated ReceptorsReceptors, G-Protein-CoupledSodium ChlorideTrace Amine-Associated ReceptorsAgingAnxietyHematologyLeukocytesNeutrophilsTAAR1ThyroidTrace amines

Identifiers

PMID31399838
PMCPMC11448943
OpenAlexW2968502993

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.