ArticleClinical oral investigations2020
Cytocompatibility, bioactivity potential, and ion release of three premixed calcium silicate-based sealers.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Postoperative pain after root canal filling with bioceramic sealers: a systematic review and meta-analysis of randomized clinical trials.Odontology · 2023Pooled it
- Biological and Mechanical Comparison of Eggshell-Derived Hydroxyapatite, Calcium Hydroxide, and Mineral Trioxide Aggregate.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Postoperative Pain After Root Canal Filling with Different Bioceramic Endodontic Sealers: A Double-Blind Randomized Clinical Pilot Trial.Healthcare (Basel, Switzerland) · 2026Article
- Influence of heat-assisted obturation on the distribution and post-setting stability of a calcium silicate-based endodontic sealer in simulated lateral canals: an in vitro study.BMC oral health · 2026Article
- Effect of Novel All-in-One Root Canal Irrigants on Dislodgement Resistance of Epoxy Resin and Hydraulic Calcium Silicate Sealers: An Ex vivo Study.European journal of dentistry · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Cytotoxicity, DNA damage, and migration of SHEDs exposed to bioactive pulp capping materials: an in vitro study.BMC oral health · 2026Article
- In Vitro Assessment of the Effects of Endodontic Sealers on Cell Viability, Adhesion, and Migration.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2025Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- Bond Strength of an Epoxy Resin Root Canal Sealer Prototype.Dentistry journal · 2025Article
- Influence of irrigating solutions on the hydration of calcium silicate-based dental biomaterials: AnJournal of conservative dentistry and endodontics · 2025Article
- Evaluation the impact of access cavity design and activation of calcium silicate-based sealer with EDDY and XP-Endo Finisher on sealer penetration into dentinal tubules: a confocal laser scanning microscopy study.Head & face medicine · 2025Article
- In vitro Evaluation of Cytotoxicity, Biocompatibility, and Osteogenic Effect of Two Calcium Silicate Sealers Compared with AH Plus Jet.European journal of dentistry · 2025Article
- Comparative evaluation of retreatability of three different bioceramic sealers using xylene in root canal retreatment - AnJournal of conservative dentistry and endodontics · 2025Article
- Article
- Calcium Silicate-Based Sealers: Apatite Deposition on Root Canal Dentin and pH Variation Analysis.European journal of dentistry · 2025Article
- Comparative analysis of the inflammatory response of human gingival fibroblasts to NeoSEALER Flo and CeraSeal bioceramic sealers: an in vitro study.BMC oral health · 2025Article
- Retrieval of AH Plus Bioceramic and Ceraseal Versus AH Plus in Endodontic Retreatment.Journal of clinical medicine · 2025Article
- The effect of different bioceramic root canal sealer removal protocols on the bond strength of composite to coronal dentin in diabetic and non-diabetic patients: an ex vivo study.BMC oral health · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCompositional modifications may alter the biological and physicochemical characteristics of calcium silicate-based sealers (CSBS) and, ultimately, their bioactivity. The main objective of this study was to evaluate the biological properties of three CSBS: EndoSequence BC Sealer, Ceraseal, and Endoseal mineral trioxide aggregate. MATERIALS AND
methodsHuman periodontal ligament stem cells (hPDLSCs) were exposed to several eluates of CSBS. The ion release profile and pH were determined, and metabolic activity and cell migration were assessed using the MTT and wound healing assays. hPDLSCs were cultured in direct contact with the surface of each material, and cell morphology and attachment were analyzed by scanning electron microscopy (SEM). Bioactivity potential was assessed by RT-qPCR and mineralization assays. Statistical differences between biomaterials were assessed using one- or two-way ANOVA (α < 0.05).
resultsAll materials showed an alkaline pH, although Endoseal exhibited a significantly higher pH compared with the other CSBS (p < 0.05). Ceraseal released significantly more Ca
conclusionsThe eluates from EndoSequence BC Sealer and Ceraseal displayed higher cell viability, cell attachment, cell migration rates, and ion release rates than Endoseal. Ceraseal and EndoSequence BC Sealer exhibited significantly more gene expression and mineralization capacity than Endoseal. CLINICAL RELEVANCE: The results obtained in the present work suggest that EndoSequence BC Sealer and Ceraseal possess biological properties that make them suitable materials for root canal treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.