Evidence map›Paper›PMID 31399793›Full record

Trial reportAIDS and behavior2019

Slow Acceptance of Universal Antiretroviral Therapy (ART) Among Mothers Enrolled in IMPAACT PROMISE Studies Across the Globe.

L Stranix-Chibanda, S Brummel, J Pilotto, M Mutambanengwe, V Chanaiwa, T Mhembere, M Kamateeka, J Aizire, G Masheto, R Chamanga and 24 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

L Stranix-ChibandaUniversity of Zimbabwe College of Health Sciences, Paediatrics and Child Health, Harare, Zimbabwe. lstranix@uzchs-ctrc.org.ORCID http://orcid.org/0000-0003-3566-1688
S BrummelHarvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research in the Department of Biostatistics, Boston, USA.
J PilottoLaboratorio de AIDS e Imunologia Molecular - Fiocruz, Hospital Geral de Nova Iguacu, Rio de Janeiro, Brazil.
M MutambanengweUniversity of Zimbabwe College of Health Sciences - Clinical Trials Research Centre, 15 Phillips Avenue, Belgravia, Harare, Zimbabwe.
V ChanaiwaUniversity of Zimbabwe College of Health Sciences - Clinical Trials Research Centre, 15 Phillips Avenue, Belgravia, Harare, Zimbabwe.
T MhembereUniversity of Zimbabwe College of Health Sciences - Clinical Trials Research Centre, 15 Phillips Avenue, Belgravia, Harare, Zimbabwe.
M KamateekaMakerere University - Johns Hopkins University Research Collaboration, Kampala, Uganda.
J AizireMakerere University - Johns Hopkins University Research Collaboration, Kampala, Uganda.
G MashetoHarvard T.H. Chan School of Public Health, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
R ChamangaCollege of Medicine - Johns Hopkins Research Project, Blantyre, Malawi.
M MaluwaUniversity of North Carolina Project, Lilongwe, Malawi.
S HanleyCentre Aids Prevention Research South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
E JoaoDepartment of Infectious Diseases, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil.
G TheronDepartment of Obstetrics and Gynaecology, Stellenbosch University, Cape Town, South Africa.
N NevrekarDepartment of Obstetrics and Gynaecology, BJ Government Medical College, Pune, India.
M NyatiPerinatal HIV Research Unit, Johannesburg, South Africa.
B SantosHospital Nossa Senhora da Conceicao, Porto Alegre, Brazil.
L AurpibulResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, China.
M Mubiana-MbeweCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
R OliveiraInstituto of Pediatrics Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
T AnekthananonFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
P MlayKilimanjaro Christian Medical Centre, Moshi, Tanzania.
K AngelidouHarvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research in the Department of Biostatistics, Boston, USA.
C TierneyHarvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research in the Department of Biostatistics, Boston, USA.
L ZiembaHarvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research in the Department of Biostatistics, Boston, USA.
A ColettiFHI 360, IMPAACT Operations Center, Durham, NC, USA.
K McCarthyFHI 360, IMPAACT Operations Center, Durham, NC, USA.
M BasarFrontier Science and Technology Research Foundation, Amherst, USA.
N ChakhtouraEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA.
R BrowningDivision of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, USA.
J CurrierDivision of Infectious Diseases, University of California Los Angeles, Los Angeles, USA.
M G FowlerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA.
P FlynnDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
PROMISE study team

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Jennifer Jao, Sharon A Nachman · 2011 to 2026
$278.1M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6M
UZ-UCSF CTUUM1AI069436 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZVAVAHERA MIKE CHIRENJE, LYNDA STRANIX-CHIBANDA · 2012 to 2026
$75.9M
UZ-UCSF Clinical Trials UnitU01AI069436 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIRENJE, ZVAVAHERA MIKE · 2007 to 2011
$49.3M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
The Johns Hopkins University - Uganda Clinical Trials UnitUM1AI069530 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MARY Glenn Fowler, Philippa Musoke · 2012 to 2026
$34.8M
Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU Y18 SupplementUM1AI069456 · NIAID · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2012 to 2026
$29.4M
Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)UM1AI069399 · NIAID · CHIANG MAI UNIVERSITY · PI Kiat Ruxrungtham, Khuanchai Supparatpinyo · 2012 to 2026
$25.0M
National Institute of Allergy and Infectious Diseases of the National Institutes of Health UM1AI068616National Institute of Allergy and Infectious Diseases of the National Institutes of Health UM1AI068632National Institute of Allergy and Infectious Diseases of the National Institutes of Health UM1AI106716NIAID NIH HHS U01 AI069436NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI069399NIAID NIH HHS UM1 AI069436NIAID NIH HHS UM1 AI069456NIAID NIH HHS UM1 AI069530NIAID NIH HHS UM1 AI106716
6 · The paper itself

Abstract

The PROMISE trial enrolled asymptomatic HIV-infected pregnant and postpartum women not eligible for antiretroviral treatment (ART) per local guidelines and randomly assigned proven antiretroviral strategies to assess relative efficacy for perinatal prevention plus maternal/infant safety and maternal health. The START study subsequently demonstrated clear benefit in initiating ART regardless of CD4 count. Active PROMISE participants were informed of results and women not receiving ART were strongly recommended to immediately initiate treatment to optimize their own health. We recorded their decision and the primary reason given for accepting or rejecting the universal ART offer after receiving the START information. One-third of participants did not initiate ART after the initial session, wanting more time to consider. Six sessions were required to attain 95% uptake. The slow uptake of universal ART highlights the need to prepare individuals and sensitize communities regarding the personal and population benefits of the "Treat All" strategy.

Indexed as

Antiretroviral Therapy, Highly ActiveAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaternal HealthMothersPatient Acceptance of Health CarePostpartum PeriodPregnancyPregnancy Complications, InfectiousYoung AdultAnti-HIV AgentsTreat AllUniversal ARTWomen with HIV

Identifiers

PMID31399793
PMCPMC6766470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.