Evidence map›Paper›PMID 31399769›Full record

ArticlePediatric radiology2019

Olfactory bulb and olfactory tract abnormalities in acrocallosal syndrome and Greig cephalopolysyndactyly syndrome.

Subramanian Subramanian, Deepa Soundara Rajan, Jenna Gaesser, Cecilia Wen-Ya Lo, Ashok Panigrahy

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Research progress of kinesin family in neurological diseases.Frontiers in cellular neuroscience · 2025
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Subramanian SubramanianDivision of Pediatric Radiology, Department of Radiology, UPMC Children's Hospital of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA, 15224, USA. drsubbusmc@yahoo.co.in.ORCID 0000-0003-2185-1931
Deepa Soundara RajanDivision of Child Neurology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Jenna GaesserDivision of Child Neurology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Cecilia Wen-Ya LoUniversity of Pittsburgh, Pittsburgh, PA, USA.
Ashok PanigrahyDivision of Pediatric Radiology, Department of Radiology, UPMC Children's Hospital of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA, 15224, USA.
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · US

Funding

Modeling the genetic basis for human congenital heart disease in miceU01HL098180 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2009 to 2014
$8.5M
SVRIII: Brain Connectome and Neurodevelopment OutcomesR01HL128818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANIGRAHY, ASHOK · 2015 to 2019
$3.5M
Modeling the complex genetics of congenital heart disease in miceR01HL132024 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2016 to 2019
$3.4M
Advanced MR Imaging of Perinatal White Matter InjuryK23NS063371 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANIGRAHY, ASHOK · 2009 to 2013
$846k
NHLBI NIH HHS R01 HL128818NHLBI NIH HHS R01 HL128818-03NHLBI NIH HHS R01 HL132024NHLBI NIH HHS U01 HL098180NINDS NIH HHS K23-063371
6 · The paper itself

Abstract

We describe association of olfactory bulb and olfactory tract abnormalities in a child with acrocallosal syndrome caused by kinesin family membrane 7 (KIF7) mutation in sonic hedgehog pathway. The child also had fontanellar bone in the anterior fontanelle, short sagittal suture, sagittal synostosis, hippocampal malrotation and Joubert malformation. Fontanellar bone has been described in GLI3 mutation and mutant mice models but has not been reported in KIF7 mutation. We briefly review the role of sonic hedgehog pathway and its components KIF7 and GLI3 in forebrain and olfactory system development and also describe olfactory system abnormality in a child with GLI3 mutation.

Indexed as

Abnormalities, MultipleAcrocallosal SyndromeAcrocephalosyndactyliaBrainChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingOlfactory BulbTomography, X-Ray ComputedAcrocallosal syndromeGreig cephalopolysyndactyly syndromeInfantMagnetic resonance imagingOlfactory bulbOlfactory tractSonic hedgehog pathway

Identifiers

PMID31399769
PMCPMC8567334
OpenAlexW2967474290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.