ArticleScientific reports2019
MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Renal protective roles of macrophage matrix metalloproteinase-12 in mice with obstructed kidneys.International journal of experimental pathology · 2024Article
- L-arginine loading porous PEEK promotes percutaneous tissue repair through macrophage orchestration.Bioactive materials · 2024Article
- MMP-12 and Periodontitis: Unraveling the Molecular Pathways of Periodontal Tissue Destruction.Journal of inflammation research · 2024Review
- On-Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole-Coated Sulfonated PEEK.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Forkhead Domain Inhibitor-6 Suppresses Corneal Neovascularization and Subsequent Fibrosis After Alkali Burn in Rats.Investigative ophthalmology & visual science · 2022Article
- Melatonin exerts anti-angiogenic and anti-inflammatory effects in alkali-burned corneas.Annals of translational medicine · 2022Article
- Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury.International journal of molecular sciences · 2022Article
- dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.Investigative ophthalmology & visual science · 2022Article
- Synthetic high-density lipoprotein nanoparticles: Good things in small packages.The ocular surface · 2021Review
- Corneal angiogenic privilege and its failure.Experimental eye research · 2021Review
- Corneal Repair Models in Mice: Epithelial/Mechanical Versus Stromal/Chemical Injuries.Methods in molecular biology (Clifton, N.J.) · 2021Article
- HDL nanoparticles have wound healing and anti-inflammatory properties and can topically deliver miRNAs.Advanced therapeutics · 2020Article
- Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer.Frontiers in oncology · 2020Article
- Gelam honey promotes ex vivo corneal fibroblasts wound healing.Cytotechnology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Following corneal injury, coordinated cellular and protein interactions occur at the wound site to restore tissue homeostasis. Regulation of this response is required to prevent the development of chronic inflammation, abnormal neovascularization, and fibrosis. The chemokine CCL2 and its primary receptor CCR2 are key regulators of the inflammatory and neovascular responses to injury. In this study, we investigated the role of macrophage-associated matrix metalloproteinase 12 (MMP12) in the regulation of CCL2 and CCR2 after corneal wounding. Using two corneal injury models, we examined the temporal and spatial expression of CCL2 and CCR2 in Mmp12
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.