ArticleNature communications2019
Virus lasers for biological detection.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Hyperspectral confocal imaging for high-throughput readout and analysis of bio-integrated microlasers.Nature protocols · 2024Review
- A biodegradable, flexible photonic patch for in vivo phototherapy.Nature communications · 2023Article
- Anomalous deep-red luminescence of perylene black analogues with strong π-π interactions.Nature communications · 2023Article
- Monitoring Various Bioactivities at the Molecular, Cellular, Tissue, and Organism Levels via Biological Lasers.Sensors (Basel, Switzerland) · 2022Review
- Polarization Angle Dependence of Optical Gain in a Hybrid Structure of Alexa-Flour 488/M13 Bacteriophage.Nanomaterials (Basel, Switzerland) · 2021Article
- Optical Detection of SARS-CoV-2 Utilizing Antigen-Antibody Binding Interactions.Sensors (Basel, Switzerland) · 2021Article
- Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives.Diagnostics (Basel, Switzerland) · 2021Review
- Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021Review
- Review of biosensing with whispering-gallery mode lasers.Light, science & applications · 2021Review
- An Analysis Review of Detection Coronavirus Disease 2019 (COVID-19) Based on Biosensor Application.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The selective amplification of DNA in the polymerase chain reaction is used to exponentially increase the signal in molecular diagnostics for nucleic acids, but there are no analogous techniques for signal enhancement in clinical tests for proteins or cells. Instead, the signal from affinity-based measurements of these biomolecules depends linearly on the probe concentration. Substituting antibody-based probes tagged for fluorescent quantification with lasing detection probes would create a new platform for biomarker quantification based on optical rather than enzymatic amplification. Here, we construct a virus laser which bridges synthetic biology and laser physics, and demonstrate virus-lasing probes for biosensing. Our virus-lasing probes display an unprecedented > 10,000 times increase in signal from only a 50% increase in probe concentration, using fluorimeter-compatible optics, and can detect biomolecules at sub-100 fmol mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.