ArticleNature communications2019
The prion-like protein kinase Sky1 is required for efficient stress granule disassembly.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- A composition-matching algorithm, MatchIDR, identifies prion-like domains that localize to stress granules.Protein science : a publication of the Protein Society · 2026Article
- Stress granules attenuate protein nanoparticle induced osmotic imbalance via membrane potential restoration.Scientific reports · 2025Article
- Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation.Molecular biology of the cell · 2025Article
- The Properties and Domain Requirements for Phase Separation of the Sup35 Prion Protein In Vivo.Biomolecules · 2023Article
- Kinase regulation by liquid-liquid phase separation.Trends in cell biology · 2023Review
- A novel SATB1 protein isoform with different biophysical properties.Frontiers in cell and developmental biology · 2023Article
- SR Protein Kinase 1 Inhibition by TAF15.Cells · 2022Article
- Protein interactions: anything new?Essays in biochemistry · 2022Article
- Nab3 nuclear granule accumulation is driven by respiratory capacity.Current genetics · 2022Article
- Protein condensation diseases: therapeutic opportunities.Nature communications · 2022Review
- Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules.Molecular cell · 2022Review
- Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives.Current genetics · 2021Review
- Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.Nature cell biology · 2021Article
- The Way forward for the Origin of Life: Prions and Prion-Like Molecules First Hypothesis.Life (Basel, Switzerland) · 2021Article
- Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2.Journal of molecular cell biology · 2021Review
- Article
- Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.eLife · 2021Article
- Stress granules display bistable dynamics modulated by Cdk.The Journal of cell biology · 2021Article
- From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies.International journal of molecular sciences · 2021Review
- Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.Frontiers in molecular biosciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Stress granules are membraneless protein- and mRNA-rich organelles that form in response to perturbations in environmental conditions. Stress granule formation is reversible, and persistent stress granules have been implicated in a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis. However, characterization of the factors involved in dissolving stress granules is incomplete. Many stress granule proteins contain prion-like domains (PrLDs), some of which have been linked to stress granule formation. Here, we demonstrate that the PrLD-containing yeast protein kinase Sky1 is a stress granule component. Sky1 is recruited to stress granules in part via its PrLD, and Sky1's kinase activity regulates timely stress granule disassembly during stress recovery. This effect is mediated by phosphorylation of the stress granule component Npl3. Sky1 can compensate for defects in chaperone-mediated stress granule disassembly and vice-versa, demonstrating that cells have multiple overlapping mechanisms for re-solubilizing stress granule components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.