ArticleNature communications2019
Fast and selective organocatalytic ring-opening polymerization by fluorinated alcohol without a cocatalyst.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 105 citations in OpenAlex.
- Proton Transfer Shuttle Mediated Dormant-Active Balance for Accelerated and Controlled Polymerization of N-Carboxyanhydrides.Angewandte Chemie (International ed. in English) · 2026Article
- Polypept(o)ide Based Biodegradable Cylindrical Polymer Brushes: Controlling Size, Shape, Surface Functionality, and Stability.ACS applied materials & interfaces · 2025Article
- Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization onACS central science · 2025Article
- Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis.Nature protocols · 2025Review
- Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications.Journal of nanobiotechnology · 2025Review
- A nanoscale MOF-based heterogeneous catalytic system for the polymerization of N-carboxyanhydrides enables direct routes toward both polypeptides and related hybrid materials.Nature communications · 2023Article
- Living/Controlled Anionic Polymerization of Glycolide in Fluoroalcohols: Toward Sustainable Bioplastics.Journal of the American Chemical Society · 2023Article
- Memory Effect in Thermoresponsive Proline-based Polymers.Angewandte Chemie (International ed. in English) · 2022Article
- Water-assisted and protein-initiated fast and controlled ring-opening polymerization of prolineNational science review · 2022Article
- Recent Advances in Poly(α-Biomolecules · 2022Review
- Article
- A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides.Nature communications · 2021Article
- Degradable polymers via olefin metathesis polymerization.Progress in polymer science · 2021Article
- Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether.Nature communications · 2021Article
- Density Functional Theory Studies on the Synthesis of Poly(α-Amino Acid)s Via the Amine-Mediated Ring Opening Polymerizations ofFrontiers in chemistry · 2021Review
- Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions.Research (Washington, D.C.) · 2021Article
- Well-Defined Construction of Functional Macromolecular Architectures Based on Polymerization of Amino Acid Urethanes.Biomedicines · 2020Review
- Facile synthesis of helical multiblock copolypeptides: minimal side reactions with accelerated polymerization ofACS macro letters · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organocatalysis is an important branch of catalysis for various organic transformations and materials preparation. Polymerizations promoted by organic catalysts can produce polymeric materials without any metallic residues, providing charming materials for high-value and sensitive domains such as biomedical applications, microelectronic devices and food packaging. Herein, we describe a fluorinated alcohol based catalytic system for polypeptide synthesis via catalytic ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydride (NCA), fulfilling cocatalyst free, metal free, high rate and high selectivity. During polymerization, the fluorinated alcohol catalyst forms multiple dynamic hydrogen bonds with the initiator, monomer and propagating polymer chain. These cooperative hydrogen bonding interactions activate the NCA monomers and simultaneously protect the overactive initiator/propagating polymer chain-ends, which offers the whole polymerization with high activity and selectivity. Mechanistic studies indicate a monocomponent-multifunctional catalytic mode of fluorinated alcohol. This finding provides a metal free and fast approach to access well-defined polypeptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.